{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:44:02Z","timestamp":1791477842198,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Thrombocytopenia (TCP) is a well\u2010known contraindication for thrombolytic therapy due to the associated risk of bleeding. This report discusses a 34\u2010year\u2010old woman presented with massive pulmonary embolism (PE) and severe TCP. She was treated with systemic thrombolysis (ST), and fortunately, a good therapeutic response was achieved without significant bleeding. Further evaluations confirmed the diagnosis of antiphospholipid syndrome for the patient. This case highlights that ST can be a viable therapeutic option for managing massive PE in thrombocytopenic patients under specific circumstances, warranting further research into its safety and efficacy.<\/jats:p>","DOI":"10.1002\/ccr3.71395","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T03:55:30Z","timestamp":1763524530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Thrombolytic Therapy for Massive Pulmonary Embolism in an Antiphospholipid Syndrome Patient With Severe Thrombocytopenia: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Arman","family":"Ahmadzadeh","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samad","family":"Nazar Poor","sequence":"additional","affiliation":[{"name":"Department of Adult Rheumatology, School of Medicine, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Hamneshin Behbahani","sequence":"additional","affiliation":[{"name":"School of Medicine, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegah","family":"Soltani","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7608-9385","authenticated-orcid":false,"given":"Arian","family":"Tavasol","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-8155","authenticated-orcid":false,"given":"Mehdi","family":"Sheibani","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5990"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1191\/1358863x02vm441cr"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017151978"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592592"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2016.08.010"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(17)30066-X"},{"issue":"1","key":"e_1_2_13_8_1","first-page":"1","article-title":"Antiphospholipid Syndrome","volume":"4","author":"Schreiber K.","year":"2018","journal-title":"Nature Reviews Disease Primers"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60709-X"},{"issue":"2","key":"e_1_2_13_10_1","first-page":"186","article-title":"Update on Thrombolytic Therapy in Acute Pulmonary Thromboembolism","volume":"51","author":"Ucar E. 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