{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T13:03:39Z","timestamp":1774616619822,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This case series describes three patients with medication\u2010related osteonecrosis of the jaw (MRONJ) treated by surgical resection combined with guided bone regeneration (GBR). All patients had a history of prolonged antiresorptive therapy and developed stage 3 MRONJ following dentoalveolar procedures. Treatment consisted of marginal resection or sequestrectomy followed by GBR using combinations of different bone substitutes, membranes, and recombinant human bone morphogenetic protein\u20102 (rhBMP\u20102). Favorable healing was observed in all cases, with progressive bone regeneration confirmed radiographically and restoration of oral function achieved in two patients through successful implant rehabilitation. These findings suggest that MRONJ resection combined with GBR offers an effective, less invasive alternative to extensive reconstructive procedures in selected MRONJ patients, supporting both functional and esthetic rehabilitation while minimizing morbidity.<\/jats:p>","DOI":"10.1002\/ccr3.71404","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T12:39:41Z","timestamp":1762951181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Guided Bone Regeneration (\n                    <scp>GBR<\/scp>\n                    ) for Reconstructing Alveolar Bone Defects Following Resective Treatment of Medication\u2010Related Osteonecrosis of the Jaws (\n                    <scp>MRONJ<\/scp>\n                    ) Lesions: A Case Series"],"prefix":"10.1002","volume":"13","author":[{"given":"Daya","family":"Masri","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9441-4066","authenticated-orcid":false,"given":"Omar","family":"Ghanaiem","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim","family":"Raiser","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaked","family":"Adut","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavriel","family":"Chaushu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, The Maurice and Gabriela Goldschleger School of Dental Medicine Tel Aviv University  Tel Aviv Israel"},{"name":"Department of Oral and Maxillofacial Surgery Rabin Medical Center  Petah Tikva Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.11.020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.6121"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-007-0540-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2022.02.008"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jormas.2018.04.006"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11071807"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/dj11060147"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12708"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2015.06.001"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2018.08.015"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2017.05.028"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2013.12.007"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.12.057"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2009.11.014"},{"issue":"6","key":"e_1_2_11_16_1","first-page":"e788","article-title":"The Assessment of Surgical and Non\u2010Surgical Treatment of Stage II Medication\u2010Related Osteonecrosis of the Jaw","volume":"22","author":"Eguchi T.","year":"2017","journal-title":"Medicina Oral, Patolog\u00eda Oral y Cirug\u00eda Bucal"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1601374"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599820949223"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9858921"}],"container-title":["Clinical Case 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