{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:27:10Z","timestamp":1765261630030,"version":"3.46.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:00:00Z","timestamp":1762646400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Persistent periradicular lesions in root canal\u2010treated teeth present a diagnostic challenge, as they may result from failed endodontic treatment, root fracture, or non\u2010endodontic pathoses. Accurate diagnosis is essential, given the significant differences in their management. This report describes a case of a persistent periradicular lesion associated with a root canal\u2010treated maxillary lateral incisor in a 45\u2010year\u2010old male. Despite nonsurgical root canal retreatment, a chronic apical abscess persisted. Cone\u2010beam computed tomography revealed a well\u2010defined radiolucency and a suspected root fracture. Exploratory surgery with methylene blue staining confirmed the root fracture. Histopathological examination of the curetted intraosseous lesion revealed a cystic lumen lined by para\u2010keratinized stratified squamous epithelium with palisaded basal cells and surface corrugation, confirming the diagnosis of an odontogenic keratocyst (OKC). The co\u2010occurrence of a root fracture and an OKC is a rare finding. This case underscores the non\u2010specific clinical and radiographic features of such entities that can mimic endodontic disease. A definitive diagnosis and successful treatment planning depend on the correlation of clinical, radiographic, and histopathological findings, highlighting the critical role of biopsy in persistent lesions.<\/jats:p>","DOI":"10.1002\/ccr3.71458","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T03:53:17Z","timestamp":1762746797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Persistent Periradicular Lesion Associated With Concurrent Root Fracture and Odontogenic Keratocyst: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8205-2087","authenticated-orcid":false,"given":"Mehdi","family":"Vatanpour","sequence":"first","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2924-724X","authenticated-orcid":false,"given":"Fatemeh","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Endodontics, Faculty of Dentistry, Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.57957"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2023.07.023"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2025.09.017"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.01.003"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103\u20106440202104742"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11121375"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6916"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13737"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12880\u2010023\u201001024\u20103"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2022.03.019"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jimaging8030051"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2023.11.003"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.943100"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.13440"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0312751"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5395\/rde.2022.47.e35"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102591.2008.01390.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iej.12220"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13931"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001\u2010024\u201001854\u2010z"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.5125\/jkaoms.2020.46.5.358"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_37_20"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/1981\u201086372015000300017576"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2022.10.005"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71458","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:53:58Z","timestamp":1765259638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ccr3.71458"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71458","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71458"}}