{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T22:24:50Z","timestamp":1772490290424,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T00:00:00Z","timestamp":1679875200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Esophageal achalasia is the most frequent primary motor disorder of the esophagus, resulting in a peristalsis and failed relaxation of the lower esophageal sphincter (LES). Various treatments have been described. Endoscopic alternatives include botulinum toxin injection and pneumatic balloon dilation, but both tend to fail with time and usually repeated interventions are required. Laparoscopic Heller myotomy (LHM) has been considered the gold standard. The diagnosis of achalasia during pregnancy is extremely rare and optimal management remains unclear. Our aim was to report a successful per oral endoscopic myotomy (POEM) performed during pregnancy. A 40\u2010year\u2010old pregnant woman presented with esophageal achalasia during her first trimester. Her disease was diagnosed with high resolution esophageal manometry (HREM). Initially an expectant conduct was attempted, but dysphagia progressed during the first 6\u2009weeks of follow\u2010up and an important weight loss was noticed. She underwent POEM at 15\u2009weeks of gestation. After the procedure, she reported relief of both dysphagia and regurgitation, and her nutritional status improved. She delivered a healthy boy at term. During follow\u2010up, she remains without dysphagia, her upper GI endoscopy shows no esophagitis and her HREM reports a normal integrated relaxation pressure. In achalasia, as in other clinical conditions, therapeutic decisions during pregnancy should always consider both the welfare of the mother and the fetus. POEM is a purely endoscopic treatment and has been recognized as a safe procedure to treat achalasia, with postoperative clinical success comparable to LHM and potential benefits over it.<\/jats:p>","DOI":"10.1002\/ccr3.7147","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T09:18:44Z","timestamp":1679908724000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Case report: Per oral endoscopic myotomy (<scp>POEM<\/scp>) during pregnancy"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-3319","authenticated-orcid":false,"given":"Ricardo J.","family":"Mej\u00eda","sequence":"first","affiliation":[{"name":"Digestive Surgery Department Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefina","family":"S\u00e1ez","sequence":"additional","affiliation":[{"name":"Pediatric Surgery Section Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A.","family":"Quitral","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo A.","family":"Monrroy","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian G.","family":"Belmar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Division Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan C.","family":"Sharp","sequence":"additional","affiliation":[{"name":"Digestive Surgery Department Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000201893.92103.94"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4819-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31818e43ab"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1905380"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-028136"},{"issue":"11","key":"e_1_2_10_7_1","first-page":"763","article-title":"Treatment of gastroesophageal reflux disease during pregnancy","volume":"8","author":"Gerson LB","year":"2012","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-011-1927-3"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm20181"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v13.i5.155"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_389_18"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2009.03.133"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rchic.2017.03.004"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.06.007"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2006.0037"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.7147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:39:03Z","timestamp":1750480743000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.7147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1002\/ccr3.7147"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.7147","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"2022-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e7147"}}