{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:26:51Z","timestamp":1765261611281,"version":"3.46.0"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Synovial sarcoma (SS) is a rare soft tissue tumor, accounting for 5%\u201310% of all soft tissue sarcomas, with an unusual occurrence in the head and neck region. This report presents a 29\u2010year\u2010old male with a biphasic SS of the left palatine tonsil, manifesting as progressive dysphagia, odynophagia, hoarseness, and left cervical lymphadenopathy. Clinical examination and imaging revealed a 4\u2009\u00d7\u20094 mass arising from the left tonsil and obstructing the oropharyngeal inlet. Left tonsillectomy was done and the histopathological evaluation revealed a biphasic SS and negative margins. The diagnosis was further supported by a positive transducin\u2010like enhancer of split\u20101 (TLE\u20101), SS translocation on chromosome 18 (SS18), and epithelial membrane antigen (EMA). The patient underwent chemotherapy and external beam radiotherapy (60\u2009Gy in 30 fractions), with significant clinical improvement. This case highlighted the importance of a multidisciplinary approach in diagnosing and managing a rare head and neck SS. Furthermore, this is the first reported case from Pakistan, emphasizing the need for awareness in atypical locations.<\/jats:p>","DOI":"10.1002\/ccr3.71475","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T06:05:37Z","timestamp":1763186737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biphasic Synovial Sarcoma of the Palatine Tonsil: A Case Report and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-321X","authenticated-orcid":false,"given":"Ramiza Ramza","family":"Ramli","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery, School of Medical Sciences, Health Campus Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahzaib","family":"Maqbool","sequence":"additional","affiliation":[{"name":"Internal Medicine, HCA Healthcare  Kansas City Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6118-717X","authenticated-orcid":false,"given":"Abdur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Benazir Bhutto Hospital  Rawalpindi Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadia","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Benazir Bhutto Hospital  Rawalpindi Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imran","family":"Khan","sequence":"additional","affiliation":[{"name":"NYC Health+Hospitals\/Woodhull  Brooklyn New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9830-5649","authenticated-orcid":false,"given":"Rahmat Gul","family":"Omarzai","sequence":"additional","affiliation":[{"name":"Nangarhar Medical Faculty  Jalalabad Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol28030177"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2018.10.026"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1077756"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/24.8.957"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2023.101618"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2016.06.008"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.47733\/GJCCR.2021.2203"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15194860"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444876"},{"issue":"1","key":"e_1_2_13_11_1","first-page":"1","article-title":"Molecular Diagnosis of Synovial Sarcoma: A Comparative Study With Histologic Correlation in Ramathibodi Hospital","volume":"12","author":"Jinawath A.","year":"2016","journal-title":"Asian Archives of Pathology"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930540206"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820715)50:2<269::AID-CNCR2820500217>3.0.CO;2-7"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198302000-00025"},{"issue":"5","key":"e_1_2_13_15_1","first-page":"851","article-title":"Synovial Sarcomas of the Head and Neck: CT and MR Imaging Findings of Eight Patients","volume":"22","author":"Rangheard A. 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