{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:47:14Z","timestamp":1780674434138,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T00:00:00Z","timestamp":1763251200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013788","name":"Facult\u00e9 des Sciences et de M\u00e9decine, Universit\u00e9 de Fribourg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013788","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>For centuries, turmeric has been utilized for its therapeutic properties; however, it is now being more frequently associated with the development of drug\u2010induced liver injury (DILI). The popularity of dietary supplements (DS) is rising, yet patients frequently omit disclosing their use to healthcare providers, as they do not perceive them as drugs. This dynamic will expose doctors to more patients suffering from the adverse effects of DS consumption. We present the case of a 61\u2010year\u2010old white European male, presenting with right upper quadrant abdominal pain, initially managed with antibiotic therapy based on radiological evidence of acute cholecystitis. The clinical course was complicated by progressive jaundice and severe hepatitis, necessitating hospital admission for comprehensive diagnostic evaluation. Despite an exhaustive assessment, a definitive etiology was elusive until the patient revealed self\u2010administration of a DS comprising turmeric and black pepper over the preceding year as adjunctive treatment for depressive symptoms. This disclosure led to the diagnosis of DILI, and complete normalization of hepatic function was observed within 2 months following discontinuation of the DS. This case underscores the potential for turmeric\u2010containing DS, particularly those combined with bioavailability enhancers such as black pepper, to trigger DILI in patients at risk. Healthcare professionals should proactively inquire about their patients' DS consumption and remain vigilant for their potential adverse effects.<\/jats:p>","DOI":"10.1002\/ccr3.71489","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T04:20:08Z","timestamp":1763353208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Drug\u2010Induced Liver Injury Associated With Turmeric and Black Pepper Based Dietary Supplements Consumption: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8965-5846","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Pugnale","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine University and Teaching Hospital  Fribourg Switzerland"},{"name":"Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"Schilter","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University and Teaching Hospital  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Galofaro","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University and Teaching Hospital  Fribourg Switzerland"},{"name":"Faculty of Science and Medicine University of Fribourg  Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-29006-0_20-1"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14460"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsufs.2024.1359040"},{"key":"e_1_2_13_5_1","unstructured":"\u201cTurmeric Liver Tox \u201d(2024) https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK548561\/."},{"key":"e_1_2_13_6_1","unstructured":"\u201cUS Sales of Herbal Supplements Increase by 9.7% in 2021. US Sales of Herbal Supplements Increase by 9.7% in 2021 \u201daccessed November 28 2024 https:\/\/www.herbalgram.org\/resources\/herbalegram\/volumes\/volume\u201019\/issue\u201011\u2010november\/news\u2010and\u2010features\u20101\/2021\u2010herb\u2010market\u2010report\/."},{"key":"e_1_2_13_7_1","unstructured":"\u201cCurcumin Market Size & Share Analysis Report Forecast 2020\u20132028 \u201d(2024) accessed November 28 2024 https:\/\/www.grandviewresearch.com\/industry\u2010analysis\/turmeric\u2010extract\u2010curcumin\u2010market."},{"key":"e_1_2_13_8_1","volume-title":"LiverTox: Clinical and Research Information on Drug\u2010Induced Liver Injury","author":"Turmeric","year":"2012"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/aimcc.2023.0090"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2022.09.026"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.8593"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168\u20108278(90)90124\u2010a"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001259"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40429\u2010021\u201000402\u20107"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.15333"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17010014"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000320"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000520"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102018\u2010224611"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:52:25Z","timestamp":1765259545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ccr3.71489"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71489","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71489"}}