{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T06:27:30Z","timestamp":1765261650403,"version":"3.46.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Red man syndrome (RMS) is an allergic reaction to vancomycin. Following an intravenous administration of vncomycin, it manifests as a rash on the face, neck, and upper trunk. No such incident has ever been documented in Ghana. Here, we talk about a rare incident of RMS in an orthopedic patient. She received 500\u2009mg of intravenous Vancomycin, which was given over 5\u2009min. She showed signs and symptoms of an allergic reaction 90\u2009s after the administration of the drug and was further resuscitated for about 30\u2009min. She underwent surgery successfully, recovered fully, and was discharged home in a stable condition. Common signs and symptoms of RMS include nausea, malaise, hypotension, and an erythematous rash on the face, arms, and upper trunk. Early resuscitative measures are paramount in preventing severe complications, including cardiac arrest.<\/jats:p>","DOI":"10.1002\/ccr3.71492","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T04:50:31Z","timestamp":1763700631000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Red Man Syndrome Diagnosed in an Orthopedic Patient"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0139-0458","authenticated-orcid":false,"given":"Kwabena","family":"Poku\u2010Yeboah","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Komfo Anokye Teaching Hospital  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patience","family":"Adjepong","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Komfo Anokye Teaching Hospital  Kumasi Ghana"},{"name":"Department of Anaesthesiology and Intensive Care, School of Medical Sciences Kwame Nkrumah University of Science and Technology  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akosua Adoma","family":"Antwi\u2010Kwarteng","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Komfo Anokye Teaching Hospital  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2558-258X","authenticated-orcid":false,"given":"Urijah Ntiamoah","family":"Osei Mensah","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care Komfo Anokye Teaching Hospital  Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/491708"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000001234"},{"key":"e_1_2_12_4_1","first-page":"325","volume-title":"Current Topics in Microbiology and Immunology","author":"David M. 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R.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.01.044"},{"issue":"3","key":"e_1_2_12_16_1","first-page":"505","article-title":"Road Less Traveled: Drug Hypersensitivity to Fluoroquinolones, Vancomycin, Tetracyclines, and Macrolides","volume":"62","author":"Haljam\u00e4e H.","year":"2011","journal-title":"Clinical Reviews in Allergy & Immunology"},{"issue":"2","key":"e_1_2_12_17_1","first-page":"209","article-title":"Influence of Antihistamine Pretreatment on Vancomycin\u2010Induced Red\u2010Man Syndrome","volume":"76","author":"Sahai J.","year":"2001","journal-title":"Anais Brasileiros de Dermatologia"},{"issue":"55","key":"e_1_2_12_18_1","first-page":"1","article-title":"Red Man Syndrome Following Intraperitoneal Vancomycin in a Child With Peritonitis","volume":"2","author":"Domis M. J.","year":"2018","journal-title":"Annals of Pharmacotherapy"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/106002809402800505"},{"issue":"1","key":"e_1_2_12_20_1","first-page":"4","article-title":"An Elderly Woman With \u201cRed Man Syndrome\u201d in Association With Oral Vancomycin Therapy: A Case Report","volume":"1","author":"Bailey P.","year":"2008","journal-title":"Cases J [Internet]"},{"issue":"1","key":"e_1_2_12_21_1","first-page":"13","article-title":"Vancomycin Flushing Syndrome Following Oral Administration of Vancomycin","volume":"120","author":"Kapitza C.","year":"2023","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/ai.1994.v94.a55251"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxaa036"},{"issue":"4","key":"e_1_2_12_24_1","first-page":"2","article-title":"Vancomycin Flushing Syndrome\u2009: A Case Report","volume":"16","author":"Shrivastava S.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.5312\/wjo.v14.i10.771"},{"issue":"0","key":"e_1_2_12_26_1","first-page":"2","article-title":"Management and Prevention of Anaphylaxis","volume":"4","author":"Irani A. M.","year":"2015","journal-title":"F1000Research"},{"issue":"1","key":"e_1_2_12_27_1","first-page":"1","article-title":"World Allergy Organization Anaphylaxis Guidelines","volume":"8","author":"Simons F. E. R.","year":"2015","journal-title":"World Allergy Organization Journal"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:52:06Z","timestamp":1765259526000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/ccr3.71492"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71492","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-01-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71492"}}