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The patient achieved complete resolution of clinical manifestations with thyroid hormone replacement therapy. Pediatricians should raise awareness of this rare and underdiagnosed disorder to avoid unnecessary tumor investigations or surgical intervention.<\/jats:p>","DOI":"10.1002\/ccr3.71527","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T03:05:29Z","timestamp":1764385529000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Van Wyk\u2013Grumbach Syndrome With Insulin Resistance in Children: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"given":"Hui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pediatrics Shengli Oil Field Central Hospital  Dongying Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaojie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, Shanghai Children's Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Gut Microbiota and Metabolic Research Center, Institute of Pediatric Infection, Immunity and Critical Care Medicine, School of Medicine, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shengli Oil Field Central Hospital  Dongying Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weicai","family":"Suo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shengli Oil Field Central Hospital  Dongying Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9390-8864","authenticated-orcid":false,"given":"Yizhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology, and Nutrition, Shanghai Children's Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Gut Microbiota and Metabolic Research Center, Institute of Pediatric Infection, Immunity and Critical Care Medicine, School of Medicine, Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8603-824X","authenticated-orcid":false,"given":"Hongfang","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Shengli Oil Field Central Hospital  Dongying Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(60)80250-8"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2013.871523"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.4086"},{"issue":"7","key":"e_1_2_12_5_1","article-title":"Van Wyk\u2010Grumbach Syndrome and Gonadectomy","volume":"11","author":"Arellano\u2010Llamas A. 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