{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:51:00Z","timestamp":1779216660728,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E.\u2009coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) causes spinal infections relatively rarely and is often closely associated with parenteral infections.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E.\u2009coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    spondylitis can cause fever and local pain and, in severe cases, can lead to bone destruction, abscess formation, and even the risk of high paraplegia. Therefore, timely and precise diagnosis and effective treatment are crucial. We report successful conservative management of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>E.\u2009coli<\/jats:italic>\n                    <\/jats:styled-content>\n                    spondylitis in a 72\u2010year\u2010old female using metagenomic sequencing\u2010guided prolonged meropenem infusion. Extending the infusion time of meropenem achieved clinical resolution without surgery, demonstrating this strategy's efficacy for carbapenem\u2010sensitive spinal infections.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71531","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:20:41Z","timestamp":1764062441000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Successful Treatment of\n                    <i>Escherichia coli<\/i>\n                    \u2010Related Spondylitis With an Extended Meropenem Infusion Time for a 72\u2010Year\u2010Old Woman: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1816-0016","authenticated-orcid":false,"given":"Wang","family":"Hongbin","sequence":"first","affiliation":[{"name":"Jining Medical University  Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Affiliated Hospital of Jining Medical University  Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Xianwei","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Affiliated Hospital of Jining Medical University  Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Affiliated Hospital of Jining Medical University  Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-1259","authenticated-orcid":false,"given":"Fan","family":"Xutao","sequence":"additional","affiliation":[{"name":"Spine Surgery Affiliated Hospital of Jining Medical University  Jining China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.10.3953\u20103961.1992"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/340102"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010003\u20102046\u2010x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.12.335"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.11.004"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5286726"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109695"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2015.1077192"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201667"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.06.030"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010\u2010023\u201002105\u20109"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.4120"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01888\u201015"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15092238"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.062349\u20100"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MRR.0000000000000664"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.16432"},{"key":"e_1_2_12_19_1","first-page":"174","article-title":"Community Acquired Spondylodiscitis caused by Escherichia coli; Case Report and Literature Review","volume":"4","author":"Del Pozo F. J.","year":"2016","journal-title":"Bulletin of Emergency and Trauma"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473\u20103099(17)30614\u2010X"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:30:41Z","timestamp":1766399441000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":19,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ccr3.71531"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71531","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,25]]},"assertion":[{"value":"2025-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71531"}}