{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:34:22Z","timestamp":1766399662425,"version":"3.48.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hypopigmented mycosis fungoides (HMF) is a variant of mycosis fungoides (MF). It is classified as a low\u2010grade lymphoproliferative disorder and is often challenging to diagnose, especially in young, darker\u2010skinned patients, due to its resemblance to benign conditions such as pityriasis alba, idiopathic macular hypomelanosis (IMH), parapsoriasis, postinflammatory hypopigmentation, vitiligo, and leprosy. We report a case of HMF in a 22\u2010year\u2010old Pakistani female presenting with progressive hypopigmented patches and plaques primarily on the back, groin, and trunk. The importance of early assessment in atypical HMF presentations is underscored by the delayed diagnosis despite multiple consultations. The diagnosis was confirmed through skin biopsy findings, which demonstrated CD4+ T\u2010cell dominance. The first treatment, which included topical steroids and narrow\u2010band UVB phototherapy, resulted in a partial remission. However, the patient relapsed within a few months and needed to be treated with methotrexate. This example highlights the importance of careful clinical, histological, and immunohistochemical testing for timely HMF detection as well as the need for vigilant monitoring to effectively manage recurrences.<\/jats:p>","DOI":"10.1002\/ccr3.71535","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T03:36:51Z","timestamp":1764214611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early\u2010Onset Hypopigmented Mycosis Fungoides in a Young Female: Navigating Diagnostic Delays and Treatment Complexities\u2014A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3286-0143","authenticated-orcid":false,"given":"Ravi","family":"Das","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Jinnah Postgraduate Medical Centre Karachi  Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0618-4237","authenticated-orcid":false,"given":"FNU","family":"Venjhraj","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Shaheed Mohtarma Benazir Bhutto Medical College Lyari  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"Dahara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jinnah Postgraduate Medical Centre (JPMC)  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7726-7518","authenticated-orcid":false,"given":"Naren Kumar","family":"Matlani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Jinnah Postgraduate Medical Centre Karachi  Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4946-8986","authenticated-orcid":false,"given":"Meva","family":"Ram","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Shaheed Mohtarma Benazir Bhutto Medical College Lyari  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5229-3448","authenticated-orcid":false,"given":"Tularam","family":"Yadav","sequence":"additional","affiliation":[{"name":"Primary Health Care Centre (PHCC), Jhorahat Morang  Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/J.1365\u20102133.2006.07526.X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2014.02.004"},{"key":"e_1_2_12_4_1","unstructured":"Wolters Kluwer UpToDate \u201cVariants of Mycosis Fungoides \u201d2024 https:\/\/www.uptodate.com\/contents\/variants\u2010of\u2010mycosis\u2010fungoides."},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD\u20102009\u201011\u2010251926"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/ABD1806\u20104841.20187106"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS13070584"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00281\u2010016\u20100594\u20109"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.24875\/GMM.20000052"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/ABD1806\u20104841.20132336"},{"key":"e_1_2_12_11_1","unstructured":"CARE Case Report Guidelines CARE \u201cCare \u201d2024 https:\/\/www.care\u2010statement.org\/checklist."},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS10102758"},{"key":"e_1_2_12_13_1","unstructured":"National Cancer Institute \u201cTable\u00a01. 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