{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:27:49Z","timestamp":1790015269686,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Amlodipine, a dihydropyridine calcium channel blocker (CCB), is commonly prescribed for hypertension and anginal chest pain. An overdose of this medication can result in life\u2010threatening complications such as vasodilatory shock and pulmonary edema. Noncardiogenic pulmonary edema in this setting is rare and not well understood. We report the case of a 57\u2010year\u2010old female with a complex medical history, including diffuse large B\u2010cell lymphoma (DLBCL) in remission, asthma, and depression, who presented after ingesting approximately 87 tablets (870\u2009mg) of amlodipine in a suicide attempt. The patient developed distributive shock requiring vasopressor support and acute hypoxic respiratory failure due to noncardiogenic pulmonary edema requiring intubation, mechanical ventilation, and intensive care unit (ICU) admission. Her course was complicated by prolonged mechanical ventilation and ventilator\u2010associated pneumonia (VAP), acute kidney injury (AKI), and metabolic derangements. With aggressive supportive therapy\u2014including vasopressors, diuresis, antibiotics, and mechanical ventilation\u2014the patient made a full recovery. This case is notable because NCPE is an uncommon manifestation of amlodipine toxicity [5], and because the patient survived despite multiple comorbidities. Early recognition and multidisciplinary management are critical to survival.<\/jats:p>","DOI":"10.1002\/ccr3.71538","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T12:52:34Z","timestamp":1764420754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Life\u2010Threatening Amlodipine Overdose: A Rare Case of Noncardiogenic Pulmonary Edema and Respiratory Failure Requiring\n                    <scp>ICU<\/scp>\n                    Care"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2567-3098","authenticated-orcid":false,"given":"Rohit","family":"Pandit","sequence":"first","affiliation":[{"name":"Tidal Health Peninsula Regional Internal Medicine  Salisbury USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Masuta","sequence":"additional","affiliation":[{"name":"Tidal Health Peninsula Regional Internal Medicine  Salisbury USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4965-1246","authenticated-orcid":false,"given":"Nishchal","family":"Regmi","sequence":"additional","affiliation":[{"name":"Kist Medical College and Teaching Hospital  Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1121-3066","authenticated-orcid":false,"given":"Anil","family":"Nepali","sequence":"additional","affiliation":[{"name":"Kathmandu University School of Medical Sciences  Dhulikhel Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7444-8966","authenticated-orcid":false,"given":"Gajendra","family":"Acharya","sequence":"additional","affiliation":[{"name":"Tidal Health Peninsula Regional Internal Medicine  Salisbury USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Jibran","sequence":"additional","affiliation":[{"name":"Tidal Health Peninsula Regional Internal Medicine  Salisbury USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heena","family":"Maharjan","sequence":"additional","affiliation":[{"name":"Tidal Health Peninsula Regional Internal Medicine  Salisbury USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nimesh","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Kist Medical College and Teaching Hospital  Lalitpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.08.027"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000278916.04569.23"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200105313442215"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0768-y"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2020.1725034"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281707"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12763"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2014.965827"},{"key":"e_1_2_12_10_1","unstructured":"F.Barrueto \u201cCalcium Channel Blocker Poisoning \u201d(2024) https:\/\/www.uptodate.com\/contents\/calcium\u2010channel\u2010blocker\u2010poisoning."},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002087"},{"issue":"1","key":"e_1_2_12_12_1","first-page":"25","article-title":"Severe Calcium Channel Blocker Overdose and Successful Management: A Case Report and Literature Review","volume":"9","author":"lau H. k.","year":"2020","journal-title":"Asia Pacific Journal of Medical Toxicology"},{"issue":"7","key":"e_1_2_12_13_1","first-page":"E166","article-title":"Extra Corporeal Membrane Oxygenation (ECMO) Review of a Lifesaving Technology","volume":"7","author":"Makdisi G.","year":"2015","journal-title":"Journal of Thoracic Disease"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.15171\/jcvtr.2018.43"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MS9.0000000000001720"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:30:49Z","timestamp":1766399449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ccr3.71538"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71538","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"assertion":[{"value":"2025-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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