{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:09:43Z","timestamp":1780088983722,"version":"3.54.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Unexplained lymphadenopathy is an often\u2010encountered symptom or abnormal finding during physical examinations in practice, and it can stem from a wide range of causes. These require multiple investigations to reach a diagnosis. One of the rare causes is Sarcoidosis, which is a multi\u2010system disease characterized by the infiltration of various organs by non\u2010necrotizing granulomas with intrathoracic involvement being the most common presentation. It has a global prevalence of approximately 5\u201364 cases per 100,000 people, depending on the region. Abdominal sarcoidosis accounts for approximately 30% of extrapulmonary manifestations. Its diagnosis presents significant challenges. We describe a case of abdominal sarcoidosis and the role of laparoscopy in diagnosis. A 44\u2010year\u2010old woman presented with 6\u2009months of easy fatigability and dull, aching abdominal pain. She also experienced occasional fever but had no history of tuberculosis exposure or associated symptoms. The general examination was unremarkable. Abdominal examination revealed splenomegaly. Ultrasound and subsequent computed tomography showed multiple enlarged lymph nodes (LNs) in the periportal, peripancreatic, mesenteric, and retroperitoneal regions, along with splenomegaly. Chest imaging revealed no significant findings. Differential diagnosis, including tuberculosis and lymphoma, was initially considered. An EUS\u2010guided biopsy of the abdominal LNs showed features of granulomatous lymphadenitis. However, the diagnosis remained unclear, prompting an FDG\u2010PET scan, which revealed findings consistent with those seen on previous imaging. Diagnostic laparoscopy was performed with periportal and peripancreatic LN sampling, along with an edge biopsy of the liver. Intraoperatively, multiple nodular hepatic and splenic lesions were identified, along with small, waxy nodules on the parietal peritoneum and enlarged periportal and peripancreatic LNs. Histopathological examination report revealed large non\u2010caseating granulomatous lesions containing epithelioid cells, suggesting sarcoidosis. Intra\u2010abdominal sarcoidosis, though rare, often presents asymptomatically, making it difficult to diagnose. Its clinical and radiological features are nonspecific and can mimic neoplastic or infectious diseases. In endemic regions of tuberculosis, its presentation can pose significant diagnostic challenges. Diagnosis relies on clinicopathologic findings and the exclusion of other granulomatous and autoimmune diseases. Diagnostic laparoscopy is required to reveal the involvement of granulomatous disease in the visceral and parietal peritoneum and reach a histopathological diagnosis. Especially in cases of isolated abdominal sarcoidosis, diagnostic laparoscopy played an important role in forming a definitive diagnosis.<\/jats:p>","DOI":"10.1002\/ccr3.71557","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T06:16:03Z","timestamp":1765347363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Abdominal Sarcoidosis: A Mystery Revisited"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8627-0452","authenticated-orcid":false,"given":"Lovenish","family":"Bains","sequence":"first","affiliation":[{"name":"Department of General Surgery Maulana Azad Medical College  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2548-0925","authenticated-orcid":false,"given":"Nidhi","family":"Paswan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Maulana Azad Medical College  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6497-4483","authenticated-orcid":false,"given":"Soukat Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of General Surgery Maulana Azad Medical College  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shramana","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Pathology Maulana Azad Medical College  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"issue":"1","key":"e_1_2_16_2_1","first-page":"19","article-title":"The WASOG Sarcoidosis Organ Assessment Instrument: An Update of a Previous Clinical Tool","volume":"31","author":"Judson M. 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