{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T22:54:26Z","timestamp":1767135266888,"version":"build-2238731810"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Exosome injections derived from human umbilical cord, with or without polydeoxyribonucleotide, induced robust regrowth, repigmentation of previously white beard hairs, and scar improvement in a 35\u2010year\u2010old man with refractory alopecia areata of the beard, suggesting a promising minimally invasive regenerative option.<\/jats:p>","DOI":"10.1002\/ccr3.71558","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:07:37Z","timestamp":1764936457000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Refractory Alopecia Areata of the Beard: Novel Improvement Through Exosome Therapy With Signs of Hair Repigmentation"],"prefix":"10.1002","volume":"13","author":[{"given":"Asem","family":"Shadid","sequence":"first","affiliation":[{"name":"Department of Dermatology King Fahad Medical City  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6577-6463","authenticated-orcid":false,"given":"Khalid Nabil","family":"Nagshabandi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danah K.","family":"AlRuhaimi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Al\u2010Omair","sequence":"additional","affiliation":[{"name":"Department of Dermatology Prince Sultan Military Medical City  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"Alsadhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Security Forces Hospital  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238\u2010020\u201000673\u2010w"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173197"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030612"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S22767"},{"key":"e_1_2_14_7_1","article-title":"Advances in Stem Cell\u2010Based Therapy for Hair Loss","volume":"8","author":"Egger A.","year":"2020","journal-title":"CellR4 Repair Replace Regen Reprogram"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba1685"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5548112"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500889"},{"issue":"7","key":"e_1_2_14_11_1","article-title":"Comparative Analysis of Plant\u2010Derived Exosomes and Their Effect on Keratinocytes","volume":"65","author":"Kim H.","year":"2022","journal-title":"Applied Biological Chemistry"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16261"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105490"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12250"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.128367"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126729"}],"updated-by":[{"DOI":"10.1002\/ccr3.71703","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T00:00:00Z","timestamp":1766275200000}}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:30:09Z","timestamp":1766399409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":15,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ccr3.71558"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71558","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2024-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71558"}}