{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T12:09:26Z","timestamp":1768219766007,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Paliperidone, a second\u2010generation antipsychotic commonly used to treat schizophrenia and schizoaffective disorder, has been rarely associated with inducing catatonia, a severe neuropsychiatric syndrome characterized by motor disturbances and altered mental status. We present two cases demonstrating variable onset of paliperidone\u2010induced catatonia: a 20\u2010year\u2010old male with acute symptoms following intramuscular loading doses and a 24\u2010year\u2010old female with a delayed presentation. Both cases highlight the clinical challenge of timely recognition, which is critical to prevent serious complications such as dehydration and respiratory failure. Assessment using the Bush\u2010Francis Catatonia Rating Scale (BFCRS) guided treatment with benzodiazepines and antipsychotic adjustments, resulting in significant symptom improvement. This case series underscores the need for heightened awareness of this rare adverse effect to facilitate early diagnosis and optimize outcomes in patients receiving paliperidone.<\/jats:p>","DOI":"10.1002\/ccr3.71571","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T04:10:05Z","timestamp":1765167005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paliperidone\u2010Induced Catatonia: Case Series and Review of Literature"],"prefix":"10.1002","volume":"13","author":[{"given":"Sikandar","family":"Saeed","sequence":"first","affiliation":[{"name":"BronxCare Health System  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-9031","authenticated-orcid":false,"given":"Sakshi","family":"Prasad","sequence":"additional","affiliation":[{"name":"BronxCare Health System  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arham","family":"Javaid","sequence":"additional","affiliation":[{"name":"BronxCare Health System  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elzar","family":"Matmusaeva","sequence":"additional","affiliation":[{"name":"BronxCare Health System  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Rocha","sequence":"additional","affiliation":[{"name":"School of Medicine American University of the Caribbean  Cupecoy Sint Maarten"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Resha","family":"Karani","sequence":"additional","affiliation":[{"name":"American University of Antigua College of Medicine  Coolidge Antigua and Barbuda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7975-1195","authenticated-orcid":false,"given":"Samkit","family":"Jain","sequence":"additional","affiliation":[{"name":"Vinnytsya National Medical University  Vinnitsiya Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khai","family":"Tran","sequence":"additional","affiliation":[{"name":"BronxCare Health System  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasidhar","family":"Gunturu","sequence":"additional","affiliation":[{"name":"BronxCare Health System  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010021\u201002062\u2010w"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268\u2010015\u20100092\u2010x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.12.036"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v6.i4.391"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050313X241229008"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"186","article-title":"Catatonia Associated With Initiating Paliperidone Treatment","volume":"11","author":"McKeown N. 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