{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:35:02Z","timestamp":1766399702226,"version":"3.48.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Subcutaneous panniculitis\u2010like T\u2010cell lymphoma (SPTCL) is a rare variant of primary cutaneous T\u2010cell lymphoma primarily affecting subcutaneous adipose tissue and mimicking lobular panniculitis. It often presents with erythematous subcutaneous nodules or plaques, and diagnosis can be challenging due to its diverse clinical manifestations. We report an unusual presentation of SPTCL in a 40\u2010year\u2010old female with recurrent, painless ulcerated plaques on the thighs and lower legs, accompanied by systemic symptoms including weight loss, fatigue, and laboratory abnormalities. Initially misdiagnosed as erythema nodosum, the patient was treated with antibiotics and corticosteroids without significant improvement. Histopathology and immunohistochemistry from skin biopsies revealed atypical lymphocytic infiltration consistent with SPTCL (CD3+, CD30+, CD4+, CD8\u2212, CD56\u2212). This case adds to the spectrum of SPTCL presentations, emphasizing the importance of considering SPTCL in panniculitis\u2010like lesions refractory to conventional treatment. Prompt histopathological evaluation with immunophenotyping is crucial for early diagnosis and appropriate management to improve patient outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.71572","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T03:59:42Z","timestamp":1764820782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual Presentation of Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma"],"prefix":"10.1002","volume":"13","author":[{"given":"Mona","family":"Alkallabi","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hend","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6577-6463","authenticated-orcid":false,"given":"Khalid Nabil","family":"Nagshabandi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Bin Idris","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal H.","family":"Abualola","sequence":"additional","affiliation":[{"name":"Department of Dermatology King Fahad Medical City  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4248-8312","authenticated-orcid":false,"given":"Naif Ahmed","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Alhumidi","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.650822"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102007\u201004\u2010087288"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.8342"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13787"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14572"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.1419\u201022"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20104632.2004.02500.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.5070\/D3202021535"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190\u20109622(03)02784\u20101"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.33160\/yam.2021.02.006"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440\u20100960.2004.00058.x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102022\u2010253469"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/23247096241253337"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199101000-00002"},{"issue":"5","key":"e_1_2_13_16_1","first-page":"394","article-title":"Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma: A Rare Skin Malignancy With Variable Clinical Features and Indolent Behavior","volume":"7","author":"Go R. 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J.","year":"2012","journal-title":"Annals of Dermatology"},{"issue":"10","key":"e_1_2_13_22_1","first-page":"976","article-title":"Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma Mimicking Chronic Venous Stasis Ulcers","volume":"42","author":"Liu H. L.","year":"2015","journal-title":"Journal of Dermatology"},{"issue":"9","key":"e_1_2_13_23_1","first-page":"997","article-title":"Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma Presenting With Ulcerated Plaques: A Rare Variant Mimicking Deep Dermal Infections","volume":"37","author":"El\u2010Sayed F.","year":"2010","journal-title":"Journal of Cutaneous Pathology"},{"issue":"5","key":"e_1_2_13_24_1","first-page":"503","article-title":"Systemic Subcutaneous Panniculitis\u2010Like T\u2010Cell Lymphoma: An Unusual Case With Localized Plaque and Systemic Involvement","volume":"27","author":"Kobayashi M.","year":"2017","journal-title":"European Journal of Dermatology"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100251\u20104"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.282419"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.04.022"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:32:30Z","timestamp":1766399550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":26,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ccr3.71572"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71572","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"type":"print","value":"2050-0904"},{"type":"electronic","value":"2050-0904"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71572"}}