{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:35:00Z","timestamp":1766399700079,"version":"3.48.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hypertension is a significant comorbidity in the New World, and its prevalence is rising. Around 5%\u201310% of cases with hypertension have secondary hypertension. Adrenal gland disease is among the common causes of secondary hypertension. We present a 57\u2010year\u2010old male with uncontrolled hypertension and a history of intracranial hemorrhage. The lab evaluation of the patient revealed a K+ of 3.8\u2009mEq\/L, Na\u2009+\u2009of 138\u2009mEq\/L, Renin of 2.6 mIU\/L, Aldosterone of 47.3\u2009ng\/dL, consistent with primary hyperaldosteronism (PHA). The patient's abdominal computed tomography (CT) revealed an adrenal mass measuring 21\u2009mm in the right adrenal gland. However, the adrenal\u2010vein sampling showed that the mass is probably not the source of aldosterone excess, and a possible diagnosis of adrenal hyperplasia was made. To investigate the adrenal incidentaloma, the 1\u2009mg overnight dexamethasone suppression test was performed. The 8\u2009a.m. cortisol and ACTH levels were reported to be 5\u2009microg\/dL and 3.2\u2009pg\/mL, and a diagnosis of mild autonomous hypercortisolism was also made. CT is not an accurate method to differentiate between an adrenal\u2010producing adenoma and bilateral idiopathic adrenal hyperplasia. Even in cases where a visible mass is detected on CT, patients aged 35 or older need to be evaluated for the cause of PHA.<\/jats:p>","DOI":"10.1002\/ccr3.71578","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T10:39:46Z","timestamp":1764499186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Challenges of Adrenal Venous Sampling for Primary Hyperaldosteronism in a Patient With Subclinical Cushing's Syndrome: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-3405","authenticated-orcid":false,"given":"Mahsa","family":"Malekian","sequence":"first","affiliation":[{"name":"Endocrine Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3724-209X","authenticated-orcid":false,"given":"Vahide","family":"Sadra","sequence":"additional","affiliation":[{"name":"Endocrine Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4735-1196","authenticated-orcid":false,"given":"Amir","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Endocrine Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-2287","authenticated-orcid":false,"given":"Javad","family":"Jalili","sequence":"additional","affiliation":[{"name":"Radiology Department, Faculty of Medicine Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-9810","authenticated-orcid":false,"given":"Hamidreza","family":"Ashayeri","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,30]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0244-2"},{"issue":"7","key":"e_1_2_13_3_1","first-page":"453","article-title":"Secondary Hypertension: Discovering the Underlying Cause","volume":"96","author":"Charles L.","year":"2017","journal-title":"American Family 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