{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T13:33:20Z","timestamp":1783344800598,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary breast melanoma is an exceedingly rare neoplasm, accounting for &lt;\u20090.5% of all malignant breast tumors. Its scarcity and highly variable clinical presentation often delay diagnosis and complicate management. We report the case of a 55\u2010year\u2010old woman with a primary non\u2010cutaneous melanoma of the right breast initially misdiagnosed as high\u2010grade ductal carcinoma. As a result of discordant biopsy results, the lesion progressed developing ulceration, tissue destruction, and axillary metastases. Definitive diagnosis was established via repeated incisional biopsies and immunohistochemistry. Management comprised neoadjuvant dacarbazine (discontinued owing to toxicity and disease progression), modified radical mastectomy, delayed split\u2010thickness skin graft, targeted antibiotic therapy for a carbapenemase\u2010producing infection, adjuvant carboplatin\u2013paclitaxel, and locoregional radiotherapy. Twelve months later, right\u2010side inguinal nodal metastases were resected and irradiated. At 18\u2010month follow\u2010up, the patient remains disease\u2010free. This case underscores the diagnostic and therapeutic challenges of primary breast melanoma and highlights the importance of early multidisciplinary care.<\/jats:p>","DOI":"10.1002\/ccr3.71608","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T03:57:22Z","timestamp":1764820642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First Case of Primary Breast Melanoma in Central America: Case Report and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2071-5264","authenticated-orcid":false,"given":"Ana","family":"Garc\u00eda\u2010Urbina","sequence":"first","affiliation":[{"name":"Department of General Surgery Manolo Morales Peralta Hospital  Managua Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3635-3744","authenticated-orcid":false,"given":"Denis","family":"Espinoza\u2010V\u00e1squez","sequence":"additional","affiliation":[{"name":"Department of Oncology Manolo Morales Peralta Hospital  Managua Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3081-7764","authenticated-orcid":false,"given":"Johanna","family":"Obreg\u00f3n\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of General Surgery Manolo Morales Peralta Hospital  Managua Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9353-4313","authenticated-orcid":false,"given":"Arlin","family":"Montoya Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Obstetric Critical Care and Internal Medicine Bertha Calder\u00f3n Roque Hospital  Managua Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37224"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.134720"},{"key":"e_1_2_13_4_1","first-page":"1709","article-title":"Primary Malignant Melanoma of the Breast: Case Report and Review of the Literature","volume":"35","author":"Drueppel D.","year":"2015","journal-title":"Anticancer Research"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2120"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2035"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-2870.126337"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80382-9"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00891.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2018.10.18"},{"key":"e_1_2_13_11_1","first-page":"8","article-title":"Primary Melanoma of the Breast Parenchyma: An Oncoplastic Approach","volume":"8","author":"Snashall E.","year":"2020","journal-title":"Plastic and Reconstructive Surgery. 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