{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:34:58Z","timestamp":1766399698307,"version":"3.48.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Kaposi sarcoma (KS) is a low\u2010grade angioproliferative tumor primarily associated with HIV but also seen in immunocompetent individuals. Its presentation can mimic infectious diseases such as Madura foot (mycetoma), a chronic granulomatous infection endemic to tropical regions. Accurate diagnosis is critical as management differs significantly between the two. We present a rare case of Kaposi sarcoma in a 40\u2010year\u2010old HIV\u2010negative female initially misdiagnosed as Madura foot. The patient underwent two wide local excisions without improvement. Symptoms persisted until the diagnosis of KS was confirmed, and she was subsequently treated with external beam radiotherapy (EBRT), receiving 45\u2009Gy in 15 fractions, which yielded a good partial clinical and radiological response and significant symptom relief. This case underscores the diagnostic complexities in endemic regions and highlights the importance of distinguishing Kaposi sarcoma from infectious diseases such as Madura foot. It also highlights the role of radiotherapy in managing KS.<\/jats:p>","DOI":"10.1002\/ccr3.71626","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T04:02:05Z","timestamp":1765166525000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rare Presentation of Kaposi Sarcoma Mimicking Madura Foot: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4341-813X","authenticated-orcid":false,"given":"Jeminah Nyeenya","family":"Nakatudde","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology Uganda Cancer Institute  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rockie","family":"Kisekka","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery St. Stephens Hospital  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4013-2476","authenticated-orcid":false,"given":"Solomon","family":"Kibudde","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Uganda Cancer Institute  Kampala Uganda"},{"name":"Department of Internal Medicine Makerere University  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012\u20100101\u2010RS"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004063421407"},{"key":"e_1_2_11_4_1","unstructured":"International Agency for Research on Cancer (IARC) \u201cUganda Cancer Fact Sheet. 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