{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:23:39Z","timestamp":1788024219974,"version":"build-2784847793"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Drug\u2010Induced Liver Injury (DILI) is a rare but potentially serious adverse effect of many commonly used medications. DILI is a diagnosis of exclusion and requires a high index of suspicion. Amoxicillin\u2010Clavulanate (A\u2010C) is a widely prescribed antibiotic known to be one of the leading causes of idiosyncratic DILI. Though well documented in Western countries, cases of DILI are less frequently reported in our region. The usual onset of DILI varies from a few days to 8\u2009weeks after initiation of medication. Here, we report a case of an atypically rapid onset of amoxicillin\u2013clavulanate induced liver injury in a 32\u2010year\u2010old female following just two doses.<\/jats:p>","DOI":"10.1002\/ccr3.71655","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T04:35:06Z","timestamp":1765168506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Rapid\u2010Onset Drug\u2010Induced Liver Injury Following Amoxicillin\u2010Clavulanate: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8607-5897","authenticated-orcid":false,"given":"Shuvam","family":"Khadka","sequence":"first","affiliation":[{"name":"B.P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abinash","family":"Dev","sequence":"additional","affiliation":[{"name":"B.P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-4901","authenticated-orcid":false,"given":"Pramodman Singh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of New Mexico  Albuquerque New Mexico USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujan","family":"Acharya","sequence":"additional","affiliation":[{"name":"B.P. Koirala Institute of Health Sciences  Dharan Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amisha","family":"Karki","sequence":"additional","affiliation":[{"name":"Khwopa Hospital  Bhaktapur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leeza","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chitwan Medical College  Bharatpur Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.34857"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562848231163410"},{"key":"e_1_2_13_4_1","volume-title":"LiverTox: Clinical and Research Information on Drug\u2010Induced Liver Injury","author":"A\u2010C","year":"2012"},{"key":"e_1_2_13_5_1","volume-title":"LiverTox: Clinical and Research Information on Drug\u2010Induced Liver Injury","author":"Roussel Uclaf Causality Assessment Method (RUCAM) in Drug Induced Liver Injury","year":"2012"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4121-6"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03307.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastro.2005.05.006"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.5.717"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32689"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.01.018"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2017.215"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.03.045"},{"issue":"12","key":"e_1_2_13_14_1","article-title":"Drug\u2010Induced Liver Injury Caused by Amoxicillin\/Clavulanate","volume":"12","author":"Ferreira I.","year":"2020","journal-title":"Cureus"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:30:36Z","timestamp":1766399436000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ccr3.71655"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71655","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71655"}}