{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:34:19Z","timestamp":1766399659070,"version":"3.48.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Severe autoimmune thrombocytopenia (ATP) in systemic lupus erythematosus (SLE) patients can be life\u2010threatening when refractory to standard treatments. Low\u2010dose splenic irradiation (LDSI) can provide temporary platelet recovery before definitive splenectomy. A 26\u2010year\u2010old woman with newly diagnosed SLE presented with severe thrombocytopenia (12,000\/\u03bcL) and life\u2010threatening bleeding. Despite multiple therapies, including prednisolone, cyclophosphamide, cyclosporine A, danazol, rituximab, and high\u2010dose IVIg, thrombocytopenia persisted. LDSI (15\u2009Gy in 15 fractions over 5\u2009weeks) was performed, leading to rapid platelet recovery and enabling safe splenectomy, resulting in long\u2010term remission. LDSI can serve as an effective bridging therapy in refractory ATP associated with SLE, allowing safer splenectomy and sustained remission.<\/jats:p>","DOI":"10.1002\/ccr3.71661","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T03:59:36Z","timestamp":1765252776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Autoimmune Thrombocytopenia Treated by Low\u2010Dose Splenic Irradiation Followed by Splenectomy in a Patient With Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4867-8143","authenticated-orcid":false,"given":"Ryosuke","family":"Hanaoka","sequence":"first","affiliation":[{"name":"Department of Rheumatology Kamitsuga General Hospital  Kanuma Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_15_2_1","DOI":"10.1097\/MD.0000000000036936"},{"doi-asserted-by":"publisher","key":"e_1_2_15_3_1","DOI":"10.1007\/PL00002384"},{"doi-asserted-by":"publisher","key":"e_1_2_15_4_1","DOI":"10.1097\/01.COC.0000017799.59129.7D"},{"doi-asserted-by":"publisher","key":"e_1_2_15_5_1","DOI":"10.2169\/naika.91.728"},{"key":"e_1_2_15_6_1","first-page":"1181","article-title":"Successful Treatment With Splenic Irradiation for Idiopathic Thrombocytopenic Purpura Associated With Primary Immunodeficiency Syndrome","volume":"40","author":"Abe K.","year":"1999","journal-title":"Rinsh\u014d Ketsueki"},{"doi-asserted-by":"publisher","key":"e_1_2_15_7_1","DOI":"10.1046\/j.1365-2141.1999.01496.x"},{"doi-asserted-by":"publisher","key":"e_1_2_15_8_1","DOI":"10.1016\/S0360-3016(98)00036-4"},{"doi-asserted-by":"publisher","key":"e_1_2_15_9_1","DOI":"10.1111\/j.1365-2141.1995.tb05271.x"},{"key":"e_1_2_15_10_1","first-page":"152","article-title":"Splenic Irradiation as a Treatment for Chronic Idiopathic Thrombocytopenic Purpura","volume":"39","author":"Cancelas J. 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