{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:33:49Z","timestamp":1766399629241,"version":"3.48.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004204","name":"Tongji University","doi-asserted-by":"publisher","award":["2021YXAL08"],"award-info":[{"award-number":["2021YXAL08"]}],"id":[{"id":"10.13039\/501100004204","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170051"],"award-info":[{"award-number":["82170051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202140257"],"award-info":[{"award-number":["202140257"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Liposomal amphotericin B (L\u2010AmB), as a modified formulation of traditional amphotericin B, have better targeting and lower toxicity. However, clinicians have limited experience with the use of L\u2010AmB for the treatment of\n                    <jats:italic>Aspergillus flavus<\/jats:italic>\n                    (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. flavus<\/jats:italic>\n                    <\/jats:styled-content>\n                    ) at present. We described two cases of immunocompetent adults; despite undergoing various antibacterial treatments, the symptoms were persistent. Based on the clinical characteristics and results of metagenomic next\u2010generation sequencing and (or) pathology, pulmonary\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. flavus<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection was confirmed. Subsequently, L\u2010AmB was added to the treatment. Following the initiation of antifungal therapy, the patients' symptoms and images were significantly improved. In conclusion, even in immunocompetent individuals, pathogen detection and pathological examination are crucial when treatment is not effective. In pulmonary\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. flavus<\/jats:italic>\n                    <\/jats:styled-content>\n                    infection, L\u2010AmB may deserve greater attention and confidence in clinic.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71688","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T15:35:58Z","timestamp":1765985758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Liposomal Amphotericin B in Treating Pulmonary\n                    <i>Aspergillus flavus<\/i>\n                    Infection in Nonneutropenic Adults: Cases Report and Literature Review"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-1027","authenticated-orcid":false,"given":"Xianqiu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxiong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Shanghai Pulmonary Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof3040057"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00003-4"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13225-018-0413-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0069-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof5030055"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.24-0046"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpmed.2020.03.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04599-9"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1413964"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1777267"},{"key":"e_1_2_11_12_1","first-page":"164","article-title":"Efficacy Comparison Between Liposomal Amphotericin B (L\u2010AmB) and Voriconazole (Vori) in a Murine Infection Model of Pulmonary Aspergillus Flavus","volume":"56","author":"Olson J. 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