{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T18:23:31Z","timestamp":1773080611942,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The most common adverse events associated with ceftazidime include hypersensitivity reactions, gastrointestinal disturbances, and transient abnormal liver function tests, whereas neutropenia is a rare complication. We present a case of ceftazidime\u2010induced agranulocytosis in an 89\u2010year\u2010old Chinese woman who presented with right upper quadrant abdominal pain, nausea, and vomiting. Imaging confirmed choledocholithiasis, cholecystitis, and hepatic cysts, and laboratory tests revealed elevated inflammatory markers. Treatment with intravenous ceftazidime initially improved her symptoms and inflammatory markers; however, severe neutropenia subsequently developed, progressing to agranulocytosis. After excluding other potential causes, ceftazidime was discontinued, and granulocyte colony\u2010stimulating factor (G\u2010CSF) was administered, leading to hematological recovery. This case underscores that ceftazidime, albeit rarely, can cause severe drug\u2010induced agranulocytosis. Clinicians should consider this possibility in cases of unexplained cytopenia, as prompt drug cessation and G\u2010CSF therapy may facilitate timely hematological recovery.<\/jats:p>","DOI":"10.1002\/ccr3.71699","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:43:48Z","timestamp":1765982628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ceftazidime\u2010Induced Agranulocytosis: A Case Report"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7747-3047","authenticated-orcid":false,"given":"Bingbin","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine Yijishan Hospital, First Affiliated Hospital of Wannan Medical College  Wuhu China"},{"name":"Department of Thyroid and Breast Surgery Yijishan Hospital, First Affiliated Hospital of Wannan Medical College  Wuhu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Yijishan Hospital, First Affiliated Hospital of Wannan Medical College  Wuhu China"},{"name":"Department of Gastrointestinal Surgery Yijishan Hospital, First Affiliated Hospital of Wannan Medical College  Wuhu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changbao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Yijishan Hospital, First Affiliated Hospital of Wannan Medical College  Wuhu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1875-9114.1984.tb03313.x"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199549040-00008"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.8.869"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-07462-2"},{"key":"e_1_2_13_6_1","first-page":"795","article-title":"Surgical and Nonsurgical Management of Gallstones","volume":"89","author":"Abraham S.","year":"2014","journal-title":"American Family Physician"},{"key":"e_1_2_13_7_1","first-page":"299","article-title":"Idiosyncratic Drug\u2010Induced Neutropenia & Agranulocytosis","volume":"110","author":"Andr\u00e8s E.","year":"2017","journal-title":"QJM: Monthly Journal of the Association of Physicians"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-9-200705010-00009"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.727717"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T10:32:11Z","timestamp":1766399531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/ccr3.71699"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71699","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71699"}}