{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:57:03Z","timestamp":1772999823914,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Solid papillary carcinoma of the breast is a rare histopathological subtype of papillary neoplasms, and its in\u00a0situ variant localized to the nipple is particularly uncommon. Current oncology literature provides limited evidence on standardized diagnostic criteria, biological behavior, and optimal treatment strategies for this entity. We describe a 73\u2010year\u2010old Chinese woman with a two\u2010year history of a left nipple mass that developed erythema and ulceration five days prior to presentation. Imaging studies (ultrasonography and MRI) identified an isolated nipple lesion (BI\u2010RADS 4b) with no other breast tissue involvement. Wide local excision confirmed solid papillary carcinoma in\u00a0situ (pTisN0M0), with pathological evaluation showing R0 resection margins. The patient received standard adjuvant endocrine therapy (letrozole 2.5\u2009mg\/day) and showed no evidence of recurrence at 9\u2009month follow\u2010up. For patients with nipple\u2010confined solid papillary carcinoma lacking high\u2010risk features, complete surgical excision constitutes the mainstay of treatment, complemented by postoperative adjuvant endocrine therapy to mitigate recurrence risk.<\/jats:p>","DOI":"10.1002\/ccr3.71760","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T07:32:36Z","timestamp":1769499156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nipple\u2010Originating Solid Papillary Carcinoma In\u00a0Situ: A Case Report and Literature Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1357-8927","authenticated-orcid":false,"given":"Yuying","family":"Yang","sequence":"first","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoliang","family":"Hao","sequence":"additional","affiliation":[{"name":"Weifang Traditional Chinese Hospital  Weifang Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Zhai","sequence":"additional","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine  Jinan Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoping","family":"Xie","sequence":"additional","affiliation":[{"name":"Weifang Traditional Chinese Hospital  Weifang Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Ma","sequence":"additional","affiliation":[{"name":"Weifang Traditional Chinese Hospital  Weifang Shandong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2021.352"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010020\u201000732\u20103"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.16794\/j.cnki.cn33\u20101207\/r.2021.05.015"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000745"},{"issue":"5","key":"e_1_2_15_6_1","first-page":"429","article-title":"Clinicopathological and Imaging Analysis of 8 Cases of Solid Papillary Carcinoma of the Breast","volume":"26","author":"Wu Z. Y.","year":"2021","journal-title":"Zhejiang Practical Medicine"},{"issue":"6","key":"e_1_2_15_7_1","first-page":"396","article-title":"Ultrasonographic Features of Solid Papillary Carcinoma of the Breast","volume":"26","author":"Zheng Y.","year":"2017","journal-title":"Journal of Oncology Imaging"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24305"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13521"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905\u2010023\u201002596\u20106"},{"key":"e_1_2_15_11_1","volume-title":"Morphological and Immunohistochemical Study of Solid Papillary Carcinoma of the Breast","author":"Fang W.","year":"2016"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010023\u201003489\u20107"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010024\u201003857\u2010x"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.13267\/j.cnki.syzlzz.2024.015"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.13362\/j.jpmed.202404012"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.12968\/hmed.2022.0439"},{"issue":"1","key":"e_1_2_15_17_1","first-page":"85","article-title":"Research Progress in Solid Papillary Carcinoma of the Breast","volume":"39","author":"Zhang H. K.","year":"2024","journal-title":"JCO Oncology Practice"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2023.03.098"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517189"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.06.016"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71760","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:23:26Z","timestamp":1772990606000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.71760"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71760","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]},"assertion":[{"value":"2025-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71760"}}