{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:13:30Z","timestamp":1769127210571,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Solid organ transplant recipients are at increased risk of acquiring serious infections. We present a case of a 48\u2010year\u2010old male with a history of renal transplantation in 2012, chronic kidney disease (CKD) Stage 4, hypertension, uncontrolled diabetes mellitus, and prior tuberculous pleural effusion. Laboratory investigations revealed significant renal impairment, persistent hyponatremia, hypokalemia, and subtherapeutic tacrolimus levels (2.50\u2009ng\/mL), reflecting challenges of CKD and chronic immunosuppression with mycophenolate mofetil and tacrolimus. Given his immunocompromised state and TB history, initial suspicion centered on intracranial TB reactivation. Brain MRI with contrast revealed a rim\u2010enhancing lesion in the right parieto\u2010occipital region with central diffusion restriction, suggestive of a cerebral abscess. Magnetic resonance spectroscopy (MRS) demonstrated elevated lactate (1.33\u2009ppm) and amino acid peaks, confirming the diagnosis and excluding tuberculoma or high\u2010grade glioma. Treatment included intravenous ceftriaxone, dexamethasone, and a CKD\u2010adjusted anti\u2010TB regimen (rifampicin, isoniazid, ethambutol, pyrazinamide), alongside phenytoin and continued immunosuppressants. This case underscores the diagnostic complexity of distinguishing cerebral abscesses from tuberculomas in post\u2010transplant patients, highlighting the pivotal role of multi\u2010modal imaging (MRI, MRS) and tailored therapy to manage infection, immunosuppression, and comorbidities effectively.<\/jats:p>","DOI":"10.1002\/ccr3.71785","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:52:36Z","timestamp":1767721956000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral Abscess Masquerading as Tuberculoma in a Post\u2010Renal Transplant Chronic Kidney Disease Patient: A Diagnostic and Therapeutic Challenge"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7338-4329","authenticated-orcid":false,"given":"Sakib","family":"Abrar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Dhaka Medical College and Hospital  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8995-1058","authenticated-orcid":false,"given":"Ibrahim","family":"Khalil","sequence":"additional","affiliation":[{"name":"Dhaka Medical College and Hospital  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3949-9388","authenticated-orcid":false,"given":"Md. Imran","family":"Hossain","sequence":"additional","affiliation":[{"name":"Manikganj Medical College and Hospital  Manikganj Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunjida Amin","family":"Promi","sequence":"additional","affiliation":[{"name":"Chattogram Medical College  Chattogram Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mjafi.2023.09.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2022.e01639"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.05.019"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.76.894.207"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.480"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.939241"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.01.034"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr\u20102021\u2010245131"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.tnmi7\u20100044\u20102017"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2018.12.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13816"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v7.i3.213"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508\u2010022\u201002009\u2010y"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0090\u20103019(97)80036\u20105"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1997.01430270090019"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71785","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71785","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71785","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:17:21Z","timestamp":1769066241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ccr3.71785"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71785","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71785"}}