{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T01:09:24Z","timestamp":1774314564440,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Immune checkpoint inhibitors (ICIs), such as sintilimab, have revolutionized non\u2010small cell lung cancer (NSCLC) treatment but can trigger immune\u2010related adverse events (irAEs). While pneumonitis is well documented, central airway obstruction (CAO) due to immune\u2010mediated necrosis is an extremely rare and life\u2010threatening phenotype that poses significant diagnostic challenges. A patient with recurrent squamous cell carcinoma of the lung achieved partial remission after two cycles of sintilimab combined with chemotherapy. However, 48\u2009h after the third cycle, the patient developed acute, severe dyspnea and hypoxemia. Emergency bronchoscopy revealed extensive necrotic material occluding the right main bronchus and carina. Pathological analysis indicated lymphocytic infiltration with necrosis, while microbiological tests were negative for pathogens. Given the temporal relationship, exclusion of alternative etiologies, and response to corticosteroids, the event was considered\n                    <jats:italic>probable<\/jats:italic>\n                    sintilimab\u2010related acute necrotizing CAO. Immediate interventional bronchoscopy with cryoablation was performed to restore airway patency. This was followed by a short course of systemic corticosteroids (methylprednisolone, then a prednisone taper). The patient's symptoms resolved completely, and follow\u2010up bronchoscopies confirmed mucosal healing without recurrence of stenosis or necrosis. This case highlights a distinct, underrecognized pulmonary irAE manifesting as acute central airway necrosis. Although a definitive causal relationship cannot be established from a single case, the clinical course strongly suggests a probable association with sintilimab.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71811","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T03:09:31Z","timestamp":1767409771000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report of Acute Central Airway Obstruction Induced by Anti\u2010\n                    <scp>PD<\/scp>\n                    \u20101 Sintilimab: Clinical Presentation and Review"],"prefix":"10.1002","volume":"14","author":[{"given":"Ting","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Hunan Provincial People's Hospital\/the First Affiliated Hospital of Hunan Normal University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Hunan Provincial People's Hospital\/the First Affiliated Hospital of Hunan Normal University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Hunan Provincial People's Hospital\/the First Affiliated Hospital of Hunan Normal University  Changsha Hunan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3800-6400","authenticated-orcid":false,"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Hunan Provincial People's Hospital\/the First Affiliated Hospital of Hunan Normal University  Changsha Hunan 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