{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:41:00Z","timestamp":1769125260980,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1515140066"],"award-info":[{"award-number":["2021B1515140066"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>APH is a rare disorder characterized by the proliferation of ALK\u2010expressing histiocytes with variable anatomical involvement; however, mammary involvement is exceptionally rare. A 32\u2010year\u2010old woman presented with a painless right breast mass. Ultrasound identified a 9\u2009\u00d7\u20098\u2009mm hypoechoic nodule, categorized as BI\u2010RADS 4A. Microscopy showed spindle cells in whorled patterns with characteristic nuclear folding. Immunohistochemistry demonstrated positivity for CD68, CD163, and ALK, and negativity for S\u2010100, CD1a, and CD207. The Ki\u201067 proliferation index was approximately 10%. Fluorescence in\u00a0situ hybridization (FISH) confirmed ALK gene rearrangement (The partner gene not identified), establishing the diagnosis of APH. The patient underwent complete resection without adjuvant therapy, and no recurrence was observed at the 15\u2010month ultrasound follow\u2010up. Accurate diagnosis of APH requires integration of histopathology, immunohistochemistry, and molecular testing to distinguish from other histiocytic disorders, with this case highlighting the rare presentation of APH in the breast.<\/jats:p>","DOI":"10.1002\/ccr3.71822","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:10:44Z","timestamp":1768558244000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ALK<\/scp>\n                    \u2010Positive Histiocytosis With Unilateral Breast Involvement: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1398-7522","authenticated-orcid":false,"given":"Xuechun","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pathology Dongguan Hospital Affiliated to Jinan University, Binhaiwan Central Hospital of Dongguan  Dongguan China"},{"name":"Department of Pathology The First Affiliated Hospital of Jinan University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics  Dongguan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Pathology Dongguan Hospital Affiliated to Jinan University, Binhaiwan Central Hospital of Dongguan  Dongguan China"},{"name":"Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics  Dongguan 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