{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:51:32Z","timestamp":1769125892003,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Post\u2010transfusion purpura (PTP) is a rare immune\u2010mediated post\u2010transfusion reaction resulting in severe thrombocytopenia. This case presents a 52\u2010year\u2010old female with profound thrombocytopenia following multiple transfusions. PTP was not initially suspected due to her history of comorbid anti\u2010phospholipid antibody syndrome (APS), chemotherapy treatments, and recent heparin exposure. Her thrombocytopenia was refractory to intravenous immunoglobulin (IVIG), and she was started on plasmapheresis (PLEX) with significant improvement in platelet counts. Positive human platelet antigen (HPA)\u20101a and HPA\u20105b antibodies later confirmed a diagnosis of PTP. This case highlights the importance of early recognition of PTP, and treatment should not be delayed while awaiting confirmatory antibody testing.<\/jats:p>","DOI":"10.1002\/ccr3.71831","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:58:36Z","timestamp":1768395516000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Diagnostic Challenge: Post\u2010Transfusion Purpura Unmasked After Multiple Transfusions"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0222-8178","authenticated-orcid":false,"given":"Jacintha","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Nebraska Medical Center\/Nebraska Medicine  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyal","family":"Gopalan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Nebraska Medical Center\/Nebraska Medicine  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-7626","authenticated-orcid":false,"given":"Tanya M.","family":"Wildes","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology\/Oncology University of Nebraska Medical Center\/Nebraska Medicine  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2002.00207.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14824"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JBM.S189176"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20093"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.942949"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V68.2.347.347"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2005.00633.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12782"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198302033080526"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208626"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-100-1-76"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197208102870608"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1978.tb14922.x"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71831","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71831","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:16:43Z","timestamp":1769066203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ccr3.71831"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71831","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71831"}}