{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:34:00Z","timestamp":1782167640674,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T00:00:00Z","timestamp":1768089600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Herpes simplex virus (HSV) infection may trigger rare vascular complications that lead to multiple cerebral hemorrhages. This case emphasizes considering HSV in unexplained cerebral hemorrhage among immunocompromised individuals with systemic symptoms, as timely antiviral treatment effectively improves clinical outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.71857","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T06:51:24Z","timestamp":1768200684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Herpes Simplex Virus Infection With Multiple Cerebral Hemorrhages: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Zhongzhan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Intensive Care Medicine Tongling People's Hospital  Tongling Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tongling People's Hospital  Tongling Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0733-7560","authenticated-orcid":false,"given":"Fugui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tongling People's Hospital  Tongling Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tongling People's Hospital  Tongling Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houqing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Tongling People's Hospital  Tongling Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117200"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0433-7"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01475.x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2701-5"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.4235\/agmr.22.0101"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(72)80082-0"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198311000-00004"},{"issue":"3","key":"e_1_2_14_9_1","first-page":"416","article-title":"Herpes Simplex Virus From the Lower Respiratory Tract in Adult Respiratory Distress Syndrome","volume":"126","author":"Tuxen D. V.","year":"1982","journal-title":"American Review of Respiratory Disease"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-025-05496-3"},{"issue":"2","key":"e_1_2_14_11_1","first-page":"66","article-title":"Herpes Simplex Virus Type 1 (HSV\u20101) Over\u2010Infection in Patients With Acute Respiratory Distress Syndrome Secondary to COVID\u201019 Pneumonia: Impact on Mortality","volume":"160","author":"P\u00e9rez\u2010Pedrero S\u00e1nchez\u2010Belmonte M. J.","year":"2023","journal-title":"Medicina Cl\u00ednica (Barcelona)"},{"issue":"8","key":"e_1_2_14_12_1","article-title":"The Diagnosis and Management of Herpes Simplex Pneumonia in the Critical Care Setting: A Comprehensive Review","volume":"15","author":"Pata R.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1231-4"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1740981"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885066620965941"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-53488-0.00011-0"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/1040841X.2021.1960483"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01675-19"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51348"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02001-z"},{"key":"e_1_2_14_21_1","article-title":"Cerebral Hemorrhage in Varicella\u2010Zoster Virus Encephalitis: A Case Study","volume":"26","author":"Li J.","year":"2025","journal-title":"American Journal of Case Reports"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1409-4"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.052145"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2021.1982373"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.03.003"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-021-02985-1"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010163"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.3171\/foc.2003.15.4.0"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.661603"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101328"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1684\/vir.2020.0862"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1708714"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000922"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03808.x"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-024-07587-5"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1134321"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2020.56"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15020439"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2024.2425744"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000554"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71857","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:20:01Z","timestamp":1769066401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ccr3.71857"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71857","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71857"}}