{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:14:12Z","timestamp":1769127252073,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tuberous sclerosis is a rare autosomal dominant genetic disorder caused by mutations in tumor suppressor genes (TSC1\/2), leading to hamartomas in multiple organs. Renal angiomyolipomas are often asymptomatic but can cause mass effects or bleeding if they enlarge, requiring treatment. A 29\u2010year\u2010old woman presented with severe left flank pain, an abdominal mass, and facial papules. Imaging revealed a large, 18.3\u2009\u00d7\u200913\u2009\u00d7\u200911.5\u2009cm mass in the lower pole of the left kidney, which was fat\u2010poor, a smaller lesion on the opposite kidney, pulmonary cysts, and osteoblastic bone lesions, all indicating tuberous sclerosis\u2010associated lymphangioleiomyomatosis. A left nephrectomy was performed, and she recovered well. Histology confirmed a renal angiomyolipoma with chronic inflammation. This case underscores the importance of nephrectomy for managing large angiomyolipomas to alleviate symptoms and improve quality of life. Managing such patients requires a multidisciplinary approach, including imaging and genetic testing, with ongoing care and surveillance to achieve better outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.71866","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:25:30Z","timestamp":1768544730000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal Angiomyolipoma in a Young Woman With Tuberous Sclerosis: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7324-1259","authenticated-orcid":false,"given":"Donald Dominick","family":"Lema","sequence":"first","affiliation":[{"name":"Faculty of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Urology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"Department of Surgery Dodoma Regional Referral Hospital  Dodoma Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartholomeo Nicholaus","family":"Ngowi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Urology Kilimanjaro Christian Medical Centre  Moshi Tanzania"},{"name":"Kilimanjaro Clinical Research Institute  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Lekei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Urology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deardiana","family":"Sengelela","sequence":"additional","affiliation":[{"name":"Faculty of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furaha","family":"Kasyupa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6304-5343","authenticated-orcid":false,"given":"Jeremia","family":"Pyuza","sequence":"additional","affiliation":[{"name":"Faculty of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7979-8058","authenticated-orcid":false,"given":"Denis","family":"Mucunguzi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine KCMC University  Moshi Tanzania"},{"name":"Department of Urology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7226-0168","authenticated-orcid":false,"given":"Alex","family":"Mremi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine KCMC University  Moshi Tanzania"},{"name":"Kilimanjaro Clinical Research Institute  Moshi Tanzania"},{"name":"Department of Pathology Kilimanjaro Christian Medical Centre  Moshi Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0387\u20107604(94)00130\u20108"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.37897\/rjn.2013.1.5"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/life15030368"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eucr.2024.102705"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102016\u2010312001"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ceo.12806"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31638"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12030956"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2012.01.009"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.15586\/jkcvhl.2017.97"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2021.07.011"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.5334\/jbsr.1536"},{"key":"e_1_2_14_14_1","unstructured":"J. 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