{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:57:18Z","timestamp":1772999838441,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary (AL) amyloidosis is a rare systemic disorder caused by extracellular deposition of monoclonal immunoglobulin light chains, resulting in multi\u2010organ dysfunction. SARS\u2010CoV\u20102 infection may induce persistent inflammatory and immune dysregulation, potentially promoting amyloid formation, although clinical evidence is limited, making the recognition of post\u2010COVID\u201019 amyloidosis clinically relevant and potentially novel. A 39\u2010year\u2010old Caucasian male presented with progressive weight loss (18\u2009kg over 6\u2009months), epigastric pain, early satiety, and hepatosplenomegaly. Ten months prior, he had recovered from COVID\u201019 with mild pulmonary involvement. Initial ultrasonography and endoscopy were unremarkable except for mild gastritis. Subsequent imaging revealed hepatosplenomegaly (liver: 200\u2009mm; spleen: 157\u2009mm) and cholestatic liver enzyme elevation. Investigations for sclerosing cholangitis were negative. Liver biopsy with Congo red staining confirmed amyloid deposition, and bone marrow analysis revealed clonal plasma cells, establishing primary (AL) amyloidosis. Echocardiography showed left ventricular hypertrophy (LVH) due to amyloid infiltration. This case underscores a possible association between SARS\u2010CoV\u20102 infection and primary amyloidosis. Post\u2010COVID inflammatory responses, elevated serum amyloid A, oxidative stress, and hypercoagulability may collectively facilitate amyloidogenic peptide formation and tissue deposition. Molecular dynamics studies further support the plausibility of SARS\u2010CoV\u20102\u2013induced amyloidogenesis. Primary amyloidosis may develop following COVID\u201019. Clinicians should consider amyloidosis in patients with unexplained weight loss, hepatosplenomegaly, or cholestatic liver enzyme abnormalities after SARS\u2010CoV\u20102 infection. Early biopsy and type\u2010specific diagnosis are essential for timely management. This case highlights the potential clinical significance of a post\u2010COVID\u201019 association, as primary amyloidosis may develop following COVID\u201019.<\/jats:p>","DOI":"10.1002\/ccr3.71871","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:54:36Z","timestamp":1769597676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary (\n                    <scp>AL<\/scp>\n                    ) Amyloidosis Following\n                    <scp>COVID<\/scp>\n                    \u201019 Infection: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Nasrin","family":"Gholami","sequence":"first","affiliation":[{"name":"Hematology and Oncology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-5793","authenticated-orcid":false,"given":"Sepideh","family":"Tahsini Tekantapeh","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-1683","authenticated-orcid":false,"given":"Amirreza","family":"Khalaji","sequence":"additional","affiliation":[{"name":"Immunology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babak","family":"Nejati","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamreza","family":"Ravaei","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2021.05.005"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05644-z"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-01661-6"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2022.2114899"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2018.1549825"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13169"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(99)01692-0"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2019.1693359"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.03.008"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.18502\/fem.v5i3.5889"},{"issue":"1","key":"e_1_2_13_12_1","article-title":"Therapeutic Impact of Tocilizumab in the Setting of Severe COVID\u201019; 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