{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:21:35Z","timestamp":1769127695323,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    bacteremia (SAB) is particularly challenging when complicated by infective endocarditis (IE), metastatic spread, or evolving antimicrobial resistance. We describe a 76\u2010year\u2010old woman with poorly\u2010controlled diabetes who presented with bilateral knee septic arthritis and persistent methicillin\u2010sensitive\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MSSA) bacteremia complicated by in\u00a0vivo emergence of oxacillin resistance despite a mecA\u2010negative genotype. Her clinical course was marked by an aortomitral intervalvular fibrosa abscess, vertebral osteomyelitis with epidural extension, a psoas abscess, and septic renal infarctions. She experienced breakthrough bacteremia despite initial clearance on oxacillin. Surgery was delayed due to intracranial hemorrhage but was ultimately enabled by middle meningeal artery embolization (MMAE). This case highlights the rare emergence of phenotypic oxacillin resistance in mecA\u2010negative MSSA during therapy and illustrates the role of MMAE in facilitating time\u2010sensitive cardiac surgery in the setting of recent intracranial bleeding. It underscores the importance of dynamic diagnostic reassessment, serial susceptibility testing, and multidisciplinary coordination in complicated SAB.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71888","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:19:39Z","timestamp":1768889979000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In Vivo Emergence of Oxacillin Resistance in\n                    <scp>mecA<\/scp>\n                    \u2010Negative\n                    <scp>MSSA<\/scp>\n                    Endocarditis With Metastatic Infection"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3648-2067","authenticated-orcid":false,"given":"Leandro","family":"Bosch","sequence":"first","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexie","family":"Carletti","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Division of Hospital Medicine, Department of Medicine Northwestern Memorial Hospital  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-9435","authenticated-orcid":false,"given":"Toluwalase","family":"Awoyemi","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Division of Hospital Medicine, Department of Medicine Northwestern Memorial Hospital  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Al\u2010Kazaz","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Division of Cardiology, Bluhm Cardiovascular Institute, Department of Medicine Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander J.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Department of Radiology Northwestern Memorial Hospital  Chicago Illinois USA"},{"name":"Ken &amp; Ruth Davee Department of Neurology Northwestern University Feinberg School of Medicine  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Young","sequence":"additional","affiliation":[{"name":"Northwestern University Feinberg School of Medicine  Chicago Illinois USA"},{"name":"Division of Hospital Medicine, Department of Medicine Northwestern Memorial Hospital  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2019.10.003"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072\u20107515(99)00211\u20102"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127385"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010023\u201004557\u20101"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz257"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/432472"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e318289ff1e"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2479"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.09.093"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2021.04.002"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735\u20101097(97)00250\u20107"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010009\u20100808\u20103"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096\u2010019\u201003659\u2010z"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2017.1331463"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088197"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiv512"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads1591"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201079256\u20108"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2019.12.140"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.05.056"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxae252"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00716\u201023"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02882\u201020"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00615\u201014"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac363"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2023.01.002"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31824d7ed2"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:18:31Z","timestamp":1769066311000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/ccr3.71888"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71888","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71888"}}