{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:56:48Z","timestamp":1772999808801,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>With the improvement of survival in multiple myeloma (MM), therapy\u2010related acute myeloid leukemia (t\u2010AML) has emerged as a clinically relevant second primary malignancy (SPM). We report a case of MM evolving into t\u2010AML after multi\u2010agent chemotherapy and review the literature on therapy\u2010related leukemias in MM. We report a case of a patient diagnosed with primary plasma cell leukemia (IgG\u2010\u03bb type, R\u2010ISS stage III) who achieved complete remission following maintenance therapy with daratumumab, lenalidomide, and dexamethasone after receiving a treatment regimen based on proteasome inhibitors. The patient progressed to therapy\u2010related acute myeloid leukemia 18\u2009months later, and we present the clinical features. Additionally, we conducted a literature review. Given the patient's age and debilitated physical condition, treatment with azacitidine combined with venetoclax was administered. Following the treatment, the patient developed grade IV post\u2010chemotherapy myelosuppression complicated by infection and extensive ischemic stroke. Despite aggressive supportive care, the patient's condition continued to deteriorate and he succumbed in August 2025. This case illustrates the leukemogenic risk of cytotoxic exposure in MM, highlights the adverse genetic profile of therapy\u2010related AML, and emphasizes the need for vigilant monitoring and preventive strategies in long\u2010term MM survivors.<\/jats:p>","DOI":"10.1002\/ccr3.71896","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T08:40:16Z","timestamp":1770021616000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapy\u2010Related Acute Myeloid Leukemia Following Plasma Cell Leukemia: A Case Report and Literature Review"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4699-8291","authenticated-orcid":false,"given":"Songdi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Hematology The First People's Hospital of Yuhang District (Zhejiang University School of Medicine First Affiliated Hospital Liangzhu Hospital)  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory of the First People's Hospital of Yuhang District  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First People's Hospital of Yuhang District (Zhejiang University School of Medicine First Affiliated Hospital Liangzhu Hospital)  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luling","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Hematology The First People's Hospital of Yuhang District (Zhejiang University School of Medicine First Affiliated Hospital Liangzhu Hospital)  Hangzhou 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