{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T23:38:24Z","timestamp":1769125104506,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>DiGeorge syndrome (22q11.2 deletion syndrome) is a congenital disorder typically identified in infancy, but adult presentations may feature autoimmune and thrombotic complications. We report a 30\u2010year\u2010old woman with known DiGeorge syndrome who presented with progressive right lower extremity pain. She had a recent history of transverse sinus stenting and was on dual anti\u2010platelet therapy with anticoagulation. Evaluation revealed left internal jugular vein thrombosis, abnormal distal pulses, and positive antiphospholipid antibodies. Her symptoms were attributed to vascular compromise in the setting of autoimmune thrombosis. This case highlights the need for vigilance for late\u2010onset thrombotic manifestations in adults with DiGeorge syndrome, especially following invasive procedures, and reinforces the value of multidisciplinary and immunologic assessment in complex cases.<\/jats:p>","DOI":"10.1002\/ccr3.71907","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T04:31:07Z","timestamp":1768969867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>DiGeorge<\/scp>\n                    Syndrome Complicated by Secondary Antiphospholipid Syndrome Presenting With Vascular Thrombosis"],"prefix":"10.1002","volume":"14","author":[{"given":"Aziz\u2010ur\u2010Rahman","family":"Khalid","sequence":"first","affiliation":[{"name":"St. Joseph University Medical Center  Paterson New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6539-0417","authenticated-orcid":false,"given":"Islam","family":"Rajab","sequence":"additional","affiliation":[{"name":"St. Joseph University Medical Center  Paterson New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0704-952X","authenticated-orcid":false,"given":"Sakeena","family":"Saife","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences An\u2010Najah National University  Nablus Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anwar","family":"Zahran","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine and Health Sciences An\u2010Najah National University  Nablus Palestine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan","family":"Makhoul","sequence":"additional","affiliation":[{"name":"St. Joseph University Medical Center  Paterson New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Munshi","sequence":"additional","affiliation":[{"name":"St. Joseph University Medical Center  Paterson New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibraheem","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"St. Joseph University Medical Center  Paterson New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lahita","sequence":"additional","affiliation":[{"name":"Institute for Autoimmune and Rheumatic Disease, St. Joseph Health  Wayne New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9081168"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875\u2010022\u201001340\u20103"},{"issue":"1","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","DOI":"10.70962\/jhi.20250190","article-title":"The Systemic Effects of 22q11.2 Deletion Syndrome on Immunity","volume":"2","author":"van Oers N. 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