{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:56:28Z","timestamp":1772999788704,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary hyperparathyroidism (PHPT) is uncommon in the pediatric population and rarely presents with overt skeletal complications such as brown tumors. This case study describes a 16\u2010year\u2010old female who initially presented with abdominal pain and was subsequently found to have severe hypercalcemia (serum calcium 16.4\u2009mg\/dL) and markedly elevated parathyroid hormone (PTH 1700\u2009pg\/mL) and bilateral nephrolithiasis. There were no features suggestive of multiple endocrine neoplasias. A history of a previously diagnosed \u201cnon\u2010ossifying fibroma\u201d in the proximal tibia was later reinterpreted as a brown tumor following the diagnosis of PHPT. Imaging studies revealed widespread bone tumors with multiple lytic lesions in long bones and the axial skeleton. Localization with a sestamibi scan confirmed a left inferior parathyroid adenoma, which was surgically resected and biopsy confirmed the same. Postoperatively, serum calcium normalized, and radiographs at follow\u2010up showed progressive healing of bone lesions. This case underscores the importance of biochemical and radiological findings for the appropriate diagnosis of PHPT, facilitating definitive surgical management and improved clinical outcomes. This case also illustrates the reversibility of skeletal changes following curative parathyroidectomy.<\/jats:p>","DOI":"10.1002\/ccr3.71956","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:29:17Z","timestamp":1769599757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Hyperparathyroidism With Brown Tumor\u2014A Case Mistaken as Non\u2010Ossifying Fibroma Resolved by Biochemical and Radiological Correlation"],"prefix":"10.1002","volume":"14","author":[{"given":"Dosti","family":"Regmi","sequence":"first","affiliation":[{"name":"Department of Pediatric Radiology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uma","family":"Bhatta","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-1082","authenticated-orcid":false,"given":"Madhur","family":"Bhattarai","sequence":"additional","affiliation":[{"name":"Institute of Medicine Tribhuvan University  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7967-0039","authenticated-orcid":false,"given":"Saurav","family":"Jha","sequence":"additional","affiliation":[{"name":"Manipal College of Medical Sciences  Pokhara Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akriti","family":"Baral","sequence":"additional","affiliation":[{"name":"Kathmandu Medical College  Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2025.101975"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0324-5.00028-6"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3146535"},{"issue":"3","key":"e_1_2_13_5_1","first-page":"289","article-title":"Parathyroid Disorders","volume":"105","author":"Sell J.","year":"2022","journal-title":"American Family Physician"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31430-7"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2012.12.008"},{"key":"e_1_2_13_8_1","volume-title":"StatPearls","author":"Pokhrel B.","year":"2024"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2007.03.004"},{"key":"e_1_2_13_10_1","volume-title":"StatPearls","author":"Anastasopoulou C.","year":"2025"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2021.06.010"},{"key":"e_1_2_13_12_1","unstructured":"\u201cNon\u2010Ossifying Fibroma\u2014Pathology\u2014Orthobullets \u201d [Internet] https:\/\/www.orthobullets.com\/pathology\/8027\/non\u2010ossifying\u2010fibroma."},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256\u2010013\u20101770\u20109"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1752\u20101947\u20105\u2010596"},{"key":"e_1_2_13_15_1","doi-asserted-by":"crossref","unstructured":"S.Hamidi S.Mottard M. J.Berthiaume J.Doyon M. J.B\u00e9gin andL.Bondaz \u201cBrown Tumor of the Iliac Crest Initially Misdiagnosed as a Giant Cell Tumor of the Bone \u201d (2020) https:\/\/edm.bioscientifica.com\/view\/journals\/edm\/2020\/1\/EDM20\u20100029.xml.","DOI":"10.1530\/EDM-20-0029"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehpc.2020.200385"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71956","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:22:48Z","timestamp":1772990568000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.71956"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71956","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71956"}}