{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:55:56Z","timestamp":1772999756437,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\u201cSIAD\u201d (syndrome of inappropriate antidiuresis) is frequently encountered in clinical practice, often necessitating the exclusion of various differential diagnoses and involving expensive treatments. In cases of SIAD concomitant with vitamin D deficiency, treatment with vitamin D supplementation may not only correct hyponatremia but also improve accompanying clinical findings, offering a cost\u2010effective alternative for clinicians. A 52\u2010year\u2010old Caucasian Turkish white male presented to the emergency department with symptoms of nausea, weakness, and altered consciousness. The patient was euvolemic. Laboratory results showed severe hyponatremia with low serum osmolality and high urine osmolality. Serum ADH levels were elevated. Extensive workup excluded other causes of SIAD. No significant pathology was detected, except for vitamin D deficiency. Following high\u2010dose vitamin D supplementation, the patient's sodium levels normalized without requiring further vasopressin receptor antagonist treatment. Long\u2010term follow\u2010up revealed that sodium levels remained within normal limits. Vitamin D deficiency is not traditionally considered among the common causes of SIAD. It may contribute to dysregulation of ADH. However, correcting this deficiency may resolve hyponatremia, making it a potentially overlooked, yet reversible, contributor. In patients with unexplained hyponatremia, vitamin D levels should be evaluated and corrected before initiating costlier treatment options.<\/jats:p>","DOI":"10.1002\/ccr3.71961","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T17:33:39Z","timestamp":1769880819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unexplained Hyponatremia Revealing Vitamin D Deficiency: A Clinical Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9618-7521","authenticated-orcid":false,"given":"Sara","family":"Yavuz Ileri","sequence":"first","affiliation":[{"name":"Nephrology Department Ankara G\u00fclhane Training and Research Hospital  Ankara T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215673"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1976.76"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.05.006"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2018.09.014"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.120873"},{"key":"e_1_2_14_7_1","first-page":"774","article-title":"Vitamin D and Hypertension","volume":"56","author":"Vaidya A.","year":"2010","journal-title":"Current Evidence and Future Directions Hypertension"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15219"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.03.004"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/16089677.2023.2178155"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/jomb\u20102015\u20100003"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endmts.2025.100275"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2010\u20100013"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02299"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71961","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71961","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:22:00Z","timestamp":1772990520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.71961"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71961","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]},"assertion":[{"value":"2025-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71961"}}