{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:56:15Z","timestamp":1772999775216,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Primary localized cutaneous amyloidosis (PCLA) of the vulva is an infrequent diagnosis. Its clinical presentation may mimic neoplastic or inflammatory lesions and could even be associated with human papillomavirus (HPV) of low or high oncogenic risk, making accurate diagnosis and exclusion of systemic involvement essential. A 73\u2010year\u2010old woman presented with a flat, macular, solitary vulvar lesion. Histologic evaluation revealed amyloid deposits in the papillary dermis, confirmed by Congo red staining and apple\u2010green birefringence. HPV genotyping identified type 40, a low\u2010risk genotype, with no evidence of intraepithelial neoplasia. The diagnosis of systemic amyloidosis was ruled out by a multidisciplinary team evaluation. A complete local excision was performed. After 33\u2009months of follow\u2010up, the patient remains in remission. This case highlights the importance of including PCLA in the differential diagnosis of vulvar lesions and suggests a potential role of HPV as a possible trigger for vulvar localized amyloidogenesis.<\/jats:p>","DOI":"10.1002\/ccr3.71966","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T10:51:11Z","timestamp":1769597471000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptomatic Vulvar Primary Cutaneous Amyloidosis Associated With Low\u2013Risk\n                    <scp>HPV<\/scp>\n                    : A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-3871","authenticated-orcid":false,"given":"Jorge","family":"Hoegl","sequence":"first","affiliation":[{"name":"C\u00e1tedra de Ginecolog\u00eda, Escuela de Medicina Jos\u00e9 Mar\u00eda Vargas, Facultad de Medicina Universidad Central de Venezuela  Caracas Venezuela"},{"name":"Centro Cl\u00ednico Profesional Caracas Unidad de Ginecolog\u00eda Oncol\u00f3gica  Caracas Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreina","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Molecular Instituto de Oncolog\u00eda y Hematolog\u00eda, MPPS  Caracas Venezuela"},{"name":"Instituto de Investigaciones Odontol\u00f3gicas Ra\u00fal Vincentelli, Facultad de Odontolog\u00eda Universidad Central de Venezuela  Caracas Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Marquez","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Caracas Unidad de Perinatolog\u00eda Dr. Freddy Guevara Zuloaga  Caracas Venezuela"},{"name":"Unidad de Atenci\u00f3n Femenina (UNIFEM)  Caracas Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ysleyer","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratorio R&amp;S Diagn\u00f3sticos  Caracas Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"issue":"11","key":"e_1_2_11_2_1","article-title":"Primary Localized Cutaneous Amyloidosis: A Systematic Review","volume":"60","author":"Kaltoft B.","year":"2013","journal-title":"Danish Medical Journal"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2018.1549825"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12247672"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13925"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.07.004"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506696"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2021.100790"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(08)74762-8"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109378(99)70684\u20108"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71966","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:22:30Z","timestamp":1772990550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.71966"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71966","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71966"}}