{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:56:13Z","timestamp":1772999773279,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Amoebiasis, a gastrointestinal infection caused by\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Entamoeba histolytica<\/jats:italic>\n                    <\/jats:styled-content>\n                    , is the third leading cause of mortality worldwide among parasitic infections with over 100,000 deaths annually. Apart from dysentery, it can manifest as extraintestinal disease, most commonly liver abscess, and rarely pulmonary, cardiac, and brain involvement. This case demonstrates the challenging management of a complicated amoebic liver abscess (ALA) with pulmonary involvement and venous thromboembolism. A 26\u2010year\u2010old male presenting with pleuritic right hypochondriac pain, fever, and dyspnoea underwent hepatobiliary ultrasonography (US) which showed a liver abscess. Computed tomography (CT) of the thorax and abdomen revealed a ruptured right liver abscess with infra\u2010diaphragmatic intrathoracic extension and right lung empyema with the presence of inferior vena cava (IVC) and right hepatic vein thrombosis, and right pulmonary embolism. He underwent placement of a percutaneous pigtail thoracostomy catheter for drainage of right lung empyema which was complicated with a bronchopleural fistula. Amoebiasis serology was later reported positive for immunoglobulin G (IgG). The patient was treated with medical therapy which included tissue and luminal amebicides and warfarin. Video\u2010assisted thoracoscopy surgery (VATS) was performed to visualize and repair the bronchopleural fistula. Follow\u2010up CT revealed significant reduction in size of the right lateral intrathoracic and liver abscess. This case underscores the importance of awareness of pulmonary involvement in ALA and the associated risk of venous thromboembolism as early detection facilitates effective management and reduces mortality.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71969","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T04:26:45Z","timestamp":1770784005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ruptured Amoebic Liver Abscess With Empyema, Venous Thromboembolism and Bronchopleural Fistula: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Nur H.","family":"Ahnal","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Hospital Pakar Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"},{"name":"Department of Internal Medicine, School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti N.","family":"Mohd Nawi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Pakar Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"},{"name":"Department of Internal Medicine, School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan S.","family":"Wan Ghazali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Pakar Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"},{"name":"Department of Internal Medicine, School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alwi","family":"Muhd Besari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Pakar Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"},{"name":"Department of Internal Medicine, School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-3071","authenticated-orcid":false,"given":"Hafsah","family":"Sazali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Pakar Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"},{"name":"Department of Internal Medicine, School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fathin","family":"Hadi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Pakar Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"},{"name":"Department of Internal Medicine, School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Kelantan Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy161"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022710"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(03)12830\u20109"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2022.08.013"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0272\u20105231(01)00008\u20109"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro\u20102023\u2010102554"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229\u20105151.134182"},{"key":"e_1_2_13_9_1","first-page":"225","article-title":"Pleuropulmonary Complications of Amebiasis: An Analysis of 153 Collected and 15 Personal Cases","volume":"5","author":"Ochsner 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