{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:20:37Z","timestamp":1778275237240,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Excessive sweating is a common side effect of antidepressants, affecting approximately 22% of patients. Antidepressant\u2010induced excessive sweating (ADIES) can significantly impair quality of life and medication adherence. This case report explores the use of Vitamin E as a novel adjunct treatment for ADIES. A woman in her 30s with major depressive disorder experienced significant improvement in depressive symptoms with venlafaxine but developed distressing night sweats at higher doses. Given the patient's reluctance to switch to a different antidepressant and to reduce polypharmacy, a trial of over\u2010the\u2010counter Vitamin E was initiated based on its prior evidence in managing hot flashes in postmenopausal women. After 3\u2009months, the patient reported a significant reduction in sweating, as measured by validated symptom severity scales (CGI\u2010S and HDSS). The case highlights Vitamin E as a potentially effective, low\u2010risk, and accessible option for ADIES, especially for patients at risk for polypharmacy. While larger studies are needed, Vitamin E may offer a simple strategy for improving quality of life and medication adherence.<\/jats:p>","DOI":"10.1002\/ccr3.71979","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:31:27Z","timestamp":1773297087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Managing Antidepressant\u2010Induced Hyperhidrosis With Vitamin E: An Over\u2010the\u2010Counter Supplement\u2013Based Approach"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7980-5923","authenticated-orcid":false,"given":"Saad","family":"Nazir","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of Texas at Tyler  Tyler Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahnoor","family":"Azmat","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Prathivadi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyaraj","family":"Bavishi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Texas Tech University Health Sciences Center  Lubbock Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasin","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Texas at Tyler  Tyler Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/JXX.0000000000000478"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22680"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2009.07.011"},{"issue":"7","key":"e_1_2_16_5_1","first-page":"28","article-title":"The Clinical Global Impressions Scale: Applying a Research Tool in Clinical Practice","volume":"4","author":"Busner J.","year":"2007","journal-title":"Psychiatry (Edgmont)"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102753.2007.00921.x"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.10.202"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.102267"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15010160"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/07399332.2022.2117815"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.2.495"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71979","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71979","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71979","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T06:07:06Z","timestamp":1774505226000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/ccr3.71979"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71979","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-07-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71979"}}