{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:57:35Z","timestamp":1772999855135,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder characterized by eczema, recurrent staphylococcal infections, and significantly elevated serum IgE levels. An 18\u2010year\u2010old female presented with acute abdominal pain and was diagnosed with a retroperitoneal abscess. She had a history of recurrent skin abscesses, otitis media, and eczema since infancy, skeletal fractures, and retained primary teeth. Laboratory findings showed a serum IgE level above 20,150\u2009U\/L and a CRP of 180.30\u2009mg\/L. Methicillin\u2010sensitive\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    <\/jats:styled-content>\n                    was cultured from the abscess drainage. The NIH\u2010HIES score was 60 points. Genetic testing identified a heterozygous\n                    <jats:italic>STAT3<\/jats:italic>\n                    variant (NM_139276.3: c.1145G&gt;A, p.(Arg382Gln)), confirming autosomal\u2010dominant HIES. This rare clinical presentation emphasizes the importance of considering HIES, even when deep\u2010seated infections develop outside typical cutaneous or pulmonary sites.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.71980","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:46:17Z","timestamp":1770266777000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>STAT3<\/scp>\n                    \u2010Mutated Hyper\u2010\n                    <scp>IgE<\/scp>\n                    Syndrome With Retroperitoneal Abscess in Adolescence"],"prefix":"10.1002","volume":"14","author":[{"given":"Hiroaki","family":"Sugiyama","sequence":"first","affiliation":[{"name":"Department of Pediatrics NHO Okayama Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5253-6569","authenticated-orcid":false,"given":"Yousuke","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NHO Okayama Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9340-2484","authenticated-orcid":false,"given":"Shintaro","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics NHO Okayama Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Aya","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery NHO Okayama Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery NHO Okayama Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takafumi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery NHO Okayama Medical Center  Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)90119-X"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.49.1.59"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-021-01051-1"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/302547"},{"key":"e_1_2_13_6_1","unstructured":"\u201cNM_139276.3(STAT3):c.1145G>A (p.Arg382Gln) and Hyper\u2010IgE Recurrent Infection Syndrome 1 Autosomal Dominant \u201d(2026) https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/RCV000019967\/."},{"key":"e_1_2_13_7_1","unstructured":"\u201cNM_139276.3(STAT3):c.1145G>A (p.Arg382Gln) \u201d(2026) https:\/\/www.ncbi.nlm.nih.gov\/clinvar\/variation\/18305\/."},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2021.07.007"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20202592"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073687"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.09.002"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-023-00776-5"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.06.041"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2024.45.8.20240123"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0429-z"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2125"}],"container-title":["Clinical Case 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