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Nonetheless, aspirin hypersensitivity complicates treatment for some patients. Desensitization processes have been identified as a viable method to circumvent this issue. This case report describes a 75\u2010year\u2010old man diagnosed with significant stenosis in the coronary artery who was scheduled for elective PCI of the right coronary artery. The patient's medical record noted a hypersensitivity to aspirin. Initially, the patient underwent successful desensitization to aspirin, allowing for treatment with aspirin and Clopidogrel. However, the need for another desensitization emerged months later, which unfortunately was unsuccessful. As a result, the patient's treatment was shifted to Ticagrelor monotherapy, a potent antiplatelet strategy, which was carried out without any complications during the follow\u2010up period.<\/jats:p>","DOI":"10.1002\/ccr3.71983","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:53:26Z","timestamp":1770443606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Management of Aspirin Intolerance After Ad Hoc\n                    <scp>PCI<\/scp>\n                    : A Case Report and a Developed Algorithm"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-8538","authenticated-orcid":false,"given":"Keyhan","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"},{"name":"Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakila","family":"Yaribash","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Mehrpooya","sequence":"additional","affiliation":[{"name":"Department of Cardiology School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40010-5_9"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.137.suppl_1.p151"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.045465"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.09.006"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae177"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae128"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.05.084"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62221-1"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.10.022"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.24.3017"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.2013.0025"},{"key":"e_1_2_13_14_1","volume-title":"Applied Therapeutics: The Clinical Use of Drugs","author":"Zeind C. 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