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In this case report, we describe a 14\u2010year\u2010old boy who developed calcinosis cutis due to extravasation of calcium gluconate, resulting in extensive tissue necrosis. Although surgical debridement and grafting were performed, the patient subsequently experienced iatrogenic post\u2010surgical graft calcinosis cutis, leading to severe hand disability. This case underscores the importance of prompt recognition and management of extravasation to prevent long\u2010term complications.<\/jats:p>","DOI":"10.1002\/ccr3.71986","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T06:24:10Z","timestamp":1770186250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Complicated Catastrophic Calcium Gluconate Extravasation: Post\u2010Surgical Graft Calcinosis Cutis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1081-9477","authenticated-orcid":false,"given":"Bahareh","family":"Abtahi\u2010Naeini","sequence":"first","affiliation":[{"name":"Pediatric Dermatology Division of Department of Pediatrics, Imam Hossein Children's Hospital Isfahan University of Medical Sciences  Isfahan Iran"},{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2366-7804","authenticated-orcid":false,"given":"Fereshte","family":"Rastegarnasab","sequence":"additional","affiliation":[{"name":"Hypertension Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7298-9262","authenticated-orcid":false,"given":"Nasim","family":"Kakavand","sequence":"additional","affiliation":[{"name":"School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2020.01942"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/NAN.0000000000000538"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.13936"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020903406"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.12951"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-9572(10)60045-9"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/11297298231169054"},{"issue":"33","key":"e_1_2_13_9_1","first-page":"547","article-title":"Extravasation Injuries of the Limbs in Neonates and Children\u2014Development of a Treatment Algorithm","volume":"118","author":"Hackenberg R. 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