{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:56:14Z","timestamp":1781758574361,"version":"3.54.5"},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Ecthyma gangrenosum (EG) is a rare but severe cutaneous infection, often caused by Gram\u2010negative organisms. It may indicate sepsis or underlying immunodeficiency, although cases in immunocompetent preterm infants are uncommon. We report the case of a preterm male neonate born at 34\u2009+\u20095\u2009weeks of gestation from a twin pregnancy, weighing 2030\u2009g. He was initially treated for presumed early\u2010onset neonatal bacterial infection with cefotaxime and gentamicin, showing good initial improvement. On Day 7 of life, erythematous plaques appeared in the right inguinal region and on the scrotum, rapidly progressing to necrotic ulcerations. Laboratory findings showed thrombocytopenia with negative C\u2010reactive protein. Ultrasound revealed scrotal and thigh infiltration without abscess or thrombosis. Skin cultures grew\n \n Klebsiella pneumoniae<\/jats:italic>\n <\/jats:styled-content>\n and\n \n Enterococcus faecium<\/jats:italic>\n <\/jats:styled-content>\n , and blood cultures isolated\n \n Enterococcus faecium<\/jats:italic>\n <\/jats:styled-content>\n . Targeted antimicrobial therapy combined with daily wound care led to complete healing with minor residual scarring. Immunologic evaluation was normal. EG can occur in preterm neonates without immunodeficiency, and early microbiological diagnosis with targeted therapy leads to favorable outcomes.\n <\/jats:p>","DOI":"10.1002\/ccr3.71993","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:02:55Z","timestamp":1770350575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non Pseudomonal Ecthyma Gangrenosum in an Immunocompetent Preterm Neonate: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-1214","authenticated-orcid":false,"given":"Abdessamad","family":"Lalaoui","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother and Child Hospital Mohamed VI UHC Marrakech Morocco"},{"name":"Research Center for Childhood, Health and Sustainable Development, FMPM Cadi Ayyad University Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1793-932X","authenticated-orcid":false,"given":"Ghizlane","family":"Kassal","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother and Child Hospital Mohamed VI UHC Marrakech Morocco"},{"name":"Research Center for Childhood, Health and Sustainable Development, FMPM Cadi Ayyad University Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3186-1909","authenticated-orcid":false,"given":"Khalid","family":"Abi el Aala","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother and Child Hospital Mohamed VI UHC Marrakech Morocco"},{"name":"Research Center for Childhood, Health and Sustainable Development, FMPM Cadi Ayyad University Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asma Lamrani","family":"Hanchi","sequence":"additional","affiliation":[{"name":"Department of Microbiology Mohamed VI UHC Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabila","family":"Soraa","sequence":"additional","affiliation":[{"name":"Department of Microbiology Mohamed VI UHC Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatiha","family":"Bennaoui","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother and Child Hospital Mohamed VI UHC Marrakech Morocco"},{"name":"Research Center for Childhood, Health and Sustainable Development, FMPM Cadi Ayyad University Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia El Idrissi","family":"Slitine","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother and Child Hospital Mohamed VI UHC Marrakech Morocco"},{"name":"Research Center for Childhood, Health and Sustainable Development, FMPM Cadi Ayyad University Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadl Mrabih Rabou","family":"Maoulainine","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Mother and Child Hospital Mohamed VI UHC Marrakech Morocco"},{"name":"Research Center for Childhood, Health and Sustainable Development, FMPM Cadi Ayyad University Marrakech Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.019"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200212000-00016"},{"key":"e_1_2_11_4_1","first-page":"261","article-title":"Ecthyma Gangrenosum Caused by Escherichia coli Bacteremia: A Case Report and Review","volume":"84","author":"Patel J. K.","year":"2009","journal-title":"Cutis"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00226.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mem.2000.110013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2005.00116.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.038"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015651"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71993","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71993","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:23:45Z","timestamp":1772990625000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.71993"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71993","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71993"}}