{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:57:15Z","timestamp":1772999835776,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Tubulointerstitial nephritis with uveitis (TINU) is an immune\u2010mediated systemic disorder most commonly described in adolescents and young adults, and its recognition in older patients remains challenging. We report the case of a 58\u2010year\u2010old woman who presented with systemic symptoms and rapidly progressive acute kidney injury. Renal function deteriorated significantly, necessitating emergency hemodialysis. Renal biopsy demonstrated acute tubulointerstitial nephritis with diffuse interstitial inflammation and minimal fibrosis. During hospitalization, ocular symptoms were identified, and a comprehensive ophthalmologic examination confirmed intermediate uveitis, establishing the diagnosis of TINU syndrome. Treatment with standard\u2010dose corticosteroid therapy resulted in rapid clinical improvement, recovery of urine output, and discontinuation of dialysis within a short period. Renal function and ocular inflammation improved in parallel. Corticosteroids were gradually tapered without relapse. At long\u2010term outpatient follow\u2010up on September 15, 2025, the patient remained clinically stable, with serum creatinine levels ranging from 60 to 70\u2009\u03bcmol\/L and no recurrence of uveitis. This case highlights an atypical presentation of TINU in an older patient complicated by severe acute kidney injury requiring dialysis and underscores the importance of considering TINU in patients with unexplained acute kidney injury and ocular manifestations, regardless of age. Early recognition and appropriate immunosuppressive therapy are essential for favorable renal and ocular outcomes.<\/jats:p>","DOI":"10.1002\/ccr3.71995","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T04:40:27Z","timestamp":1770266427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Atypical Presentation of Tubulointerstitial Nephritis With Uveitis (\n                    <scp>TINU<\/scp>\n                    ) in an Older Patient Requiring Emergency Dialysis: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Yuli","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Hemodialysis Centre The First Affiliated Hospital, Jinan University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangna","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital, Jinan University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hemodialysis Centre The First Affiliated Hospital, Jinan University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital, Jinan University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-2417","authenticated-orcid":false,"given":"Wenyu","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital, Jinan University  Guangzhou Guangdong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90390-3"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.04.019"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2017.11.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.892788"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12116"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0376"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/8.9.821"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(01)00261-2"},{"issue":"1","key":"e_1_2_11_10_1","first-page":"59","article-title":"Bilateral Intermediate Uveitis and Acute Interstitial Nephritis (TINU Syndrome). Ultrasonographic Documentation of a Case","volume":"17","author":"Cavazza S.","year":"1994","journal-title":"Journal Fran\u00e7ais d'Ophtalmologie"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(98)00430-9"},{"key":"e_1_2_11_12_1","first-page":"73","article-title":"Tubulointerstitial Nephritis\u2010Uveitis (TINU)\u2010Syndrome With Posterior Uveitis","volume":"261","author":"Waeben M.","year":"1996","journal-title":"Bulletin de la Soci\u00e9t\u00e9 Belge d'Ophtalmologie"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02540313"},{"key":"e_1_2_11_14_1","first-page":"1","article-title":"Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome: A Review","volume":"0","author":"Amaro D.","year":"2019","journal-title":"British Journal of Ophthalmology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-004-1429-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00393-012-1100-y"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71995","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.71995","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.71995","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:23:42Z","timestamp":1772990622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.71995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.71995"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.71995","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71995"}}