{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:04:38Z","timestamp":1784307878090,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T00:00:00Z","timestamp":1779494400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Psoriasis is an immune\u2010mediated skin disease in which genetic and environmental factors have a significant role. Olive oil with antioxidant properties is an effective adjunct treatment for skin diseases. Furthermore, ozone by introducing O\n                    <jats:sub>2<\/jats:sub>\n                    into the bloodstream controls the response of cell\u2010mediated immunity and leads to improve disease. So, the aim of this study was to evaluate the efficacy of ozone therapy in the treatment of Psoriasis. Topical therapy of lesions of a man suffering from psoriasis was carried out using ozonate olive oil two times a day and ozone sauna once a week during a month. Patient showed considerable improvement after about twenty days. As the itching and silvery\u2010white scaling decreased, the lesions began to resolve after three weeks. Furthermore, no recurrence was noted after 3\u2009months of follow\u2010up. It is suggested that ozone therapy, in appropriate formulations and in controlled cases, has a role in the treatment of patients with psoriasis by inhibiting the inflammatory pathways and prompting regenerative characteristics, without significant adverse effects and the necessity for systemic pharmacological agents. So, more studies on a greater population are needed to confirm this finding.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.72021","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T07:07:42Z","timestamp":1779520062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Ozone Therapy on Psoriasis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4995-8773","authenticated-orcid":false,"given":"Maryam","family":"Aghaei","sequence":"first","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4623-289X","authenticated-orcid":false,"given":"Shahrzad","family":"Aghaei","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine School of Advanced Technologies, Shahrekord University of Medical Sciences  Shahrekord Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-8985","authenticated-orcid":false,"given":"Zabihollah","family":"Shahmoradi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Dermatology Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6143-8039","authenticated-orcid":false,"given":"Mohammad\u2010Ali","family":"Nilforoushzadeh","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8787-4162","authenticated-orcid":false,"given":"Seyed","family":"Hossein Hejazi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Parasitology and Mycology School of Medicine, Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2015.07.008"},{"key":"e_1_2_13_3_1","volume-title":"Psoriasis: Handbook of Dermatology and Venereology","author":"Lo K.","year":"1997"},{"key":"e_1_2_13_4_1","volume-title":"Text Book of Dermatology","author":"Camp R.","year":"1998"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0595-442"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1995.tb04653.x"},{"key":"e_1_2_13_7_1","volume-title":"Pocket Companion to Robbins Pathologic Basis of Disease","author":"Robbins S. L.","year":"2002"},{"key":"e_1_2_13_8_1","first-page":"888","volume-title":"Medical Microbiology, A Guide to Diagnosis and Control of Infection","author":"Cruickshan K.","year":"1968"},{"key":"e_1_2_13_9_1","volume-title":"British Herbal Compendium. Volume 1. A Handbook of Scientific Information on Widely Used Plant Drugs. Companion to Volume 1 of the British Herbal Pharmacopoeia","author":"Bradley P. R.","year":"1992"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-9912-1-29"},{"issue":"1","key":"e_1_2_13_11_1","first-page":"25","article-title":"The Therapeutic Effect of Ozonated Olive Oil Plus Glucantime on Human Cutaneous Leishmaniasis","volume":"22","author":"Aghaei M.","year":"2019","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106191"},{"key":"e_1_2_13_13_1","article-title":"Application of Ozonized Oils in Human Body and Oral Cavity Systems","volume":"70","author":"Brito J\u00fanior A. A.","year":"2022","journal-title":"RGO"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25020334"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0965-2299(03)00120-1"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.41940"},{"key":"e_1_2_13_17_1","unstructured":"E.Recio M.Rodr\u00edguez C.Harrys I.Cuesta Y.Mapol\u00f3n andJ. L.Rodr\u00edguez \u201cApplication of Ozone Therapy in Patients With Psoriasis \u201d (Cuba)."},{"issue":"22","key":"e_1_2_13_18_1","first-page":"809","article-title":"Possible Protective Effect of Ozone Therapy in Imiquimod Induced Psoriasis Like Inflammation in Mice","volume":"2","author":"Abdulsalam R.","year":"2022","journal-title":"HIV Nursing"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.25251\/skin.9.2.1"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phanu.2016.10.002"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108851"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72021","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:21:45Z","timestamp":1784305305000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,23]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/ccr3.72021"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72021","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,23]]},"assertion":[{"value":"2025-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72021"}}