{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T07:55:29Z","timestamp":1774511729673,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T00:00:00Z","timestamp":1771891200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Macrodystrophia lipomatosa (MDL) is a rare sporadic, nonhereditary developmental condition, typically presenting at birth or in early childhood. It is characterized by progressive overgrowth of tissues, mainly due to excess fibrofatty tissue proliferation. This abnormal growth commonly involves nerve sheath, muscle, periosteum, and bone marrow. Herein, we present a case of a 10\u2010month\u2010old boy who was referred to our institution for evaluation of unilateral right lower limb enlargement. Clinical examination revealed soft tissue hypertrophy and syndactyly of the right lower limb. To assess the extent of limb involvement and differentiate MDL from other causes of overgrowth syndromes, a series of imaging studies was conducted. Upon confirmation of diagnosis, the patient was referred to the pediatric surgery department. The study highlights the characteristic clinical and imaging features of MDL, with particular emphasis on the MRI findings, which are essential for accurate diagnosis and differentiation from other causes of limb overgrowth.<\/jats:p>","DOI":"10.1002\/ccr3.72036","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:01:41Z","timestamp":1772964101000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Macrodystrophia Lipomatosa: A Rare Case of Right Lower Extremity Gigantism Associated With Syndactyly"],"prefix":"10.1002","volume":"14","author":[{"given":"Hafiza Sameeya","family":"Shehzadi","sequence":"first","affiliation":[{"name":"Senior Registrar Radiology Department Gujranwala Medical College Teaching Hospital  Gujranwala Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saumara","family":"Atif","sequence":"additional","affiliation":[{"name":"Radiology Department Gujranwala Medical College Teaching Hospital  Gujranwala Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iqbal Hussain","family":"Dogar","sequence":"additional","affiliation":[{"name":"Head of Department of Radiology Gujranwala Medical College Teaching Hospital  Gujranwala Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usama","family":"Siddique","sequence":"additional","affiliation":[{"name":"Faisalabad Medical University  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8208-0689","authenticated-orcid":false,"given":"Kamil Ahmad","family":"Kamil","sequence":"additional","affiliation":[{"name":"Mirwais Regional Hospital  Kandahar Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,24]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","first-page":"308","article-title":"Makrodystrophia Lipomatosa Progressiva","volume":"260","author":"Feriz H.","year":"1926","journal-title":"Virchows Archiv fur Pathologische Anatomie und Physiologie und fur Klinische Medizin [Internet]"},{"issue":"1","key":"e_1_2_13_3_1","first-page":"44","article-title":"Makrodakttll: Naddr BBR Patolojjnnn Radyolojjk Bulgulari Macrodactyly: Radiologic Findings of a Rare Anomaly","volume":"26","author":"Orhan S.","year":"2004","journal-title":"Erciyes Medical Journal"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foot.2014.03.003"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcle.2021.03.018"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2003.11.004"},{"issue":"2","key":"e_1_2_13_7_1","article-title":"Occult Lipomatosis of the Nerve as Part of Macrodystrophia Lipomatosa: Illustrative Case","volume":"5","author":"Marek T.","year":"2023","journal-title":"Journal of Neurosurgery: Case Lessons [Internet]"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2025.111751"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246166"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.25259\/JCIS-9-4"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.5334\/jbsr.3522"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2021.106181"}],"container-title":["Clinical Case 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