{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:59:32Z","timestamp":1777006772632,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A previously healthy 19\u2010year\u2010old male presented with 1\u2009day of transient right\u2010sided weakness, numbness, and gait disequilibrium after recent self\u2010limited sinonasal symptoms and minor nasal trauma with epistaxis. He was afebrile but with focal deficits, leukocytosis, and elevated C\u2010reactive protein. Noncontrast head CT showed a left frontal lesion with vasogenic edema; MRI demonstrated a 2.4\u2009\u00d7\u20091.4\u2009cm rim\u2010enhancing lesion in the left paramedian precentral gyrus with homogeneous diffusion restriction, low apparent diffusion coefficient, and surrounding edema. Stereotactic aspiration was performed within 24\u2009h of presentation to obtain microbiological diagnosis and source control. A neuronavigated, transgyral frontal approach was used to avoid eloquent cortex. Empiric antimicrobials were initiated immediately after operative sampling. Postoperatively, the patient developed transient distal right lower extremity weakness that improved with supportive care and physical therapy. A thorough cardiac, dental, and thoracic evaluation did not reveal a source; the case was deemed cryptogenic. Operative cultures grew\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Streptococcus intermedius<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Aggregatibacter aphrophilus<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Targeted intravenous therapy was administered with near\u2010complete radiographic resolution and full neurologic recovery at 4\u2010month follow\u2010up. This case emphasizes three practical principles for trainees: maintain suspicion for intracranial infection in afebrile young patients with new focal deficits and recent sinonasal symptoms; prioritize microbiological diagnosis and source control, while not delaying empiric therapy; and plan stereotactic trajectories that respect eloquent cortex and anticipate transient postoperative deficits. Early imaging, meticulous source evaluation and control, and directed therapy remain central to outcome.\n                  <\/jats:p>","DOI":"10.1002\/ccr3.72056","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:25:07Z","timestamp":1777004707000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cryptogenic Perirolandic Brain Abscess in an Otherwise Healthy Young Man"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8133-6929","authenticated-orcid":false,"given":"Mazen","family":"Taman","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl","family":"Porto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Luc","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Farmakiotis","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Beth Israel Deaconess Medical Center Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athar N.","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,23]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijsu.2010.11.005","article-title":"Brain Abscess: An Overview","volume":"9","author":"Muzumdar D.","year":"2011","journal-title":"International Journal of Surgery"},{"issue":"1","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cmi.2019.05.016","article-title":"Incidence and Mortality of Brain Abscess in Denmark: A Nationwide Population\u2010Based Study","volume":"26","author":"Bodilsen J.","year":"2020","journal-title":"Clinical Microbiology and Infection"},{"key":"e_1_2_12_4_1","volume-title":"Brain Abscess","author":"Bokhari M. 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Isolated From a Brain Abscess in a 4\u2010Year\u2010Old Child","volume":"25","author":"Ivaska L.","year":"2019","journal-title":"Journal of Infection and Chemotherapy"},{"issue":"1","key":"e_1_2_12_19_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13104-016-2223-z","article-title":"Late Infectious Endocarditis of Surgical Patch Closure of Atrial Septal Defects Diagnosed by 18F\u2010Fluorodeoxyglucose Gated Cardiac Computed Tomography (18F\u2010FDG\u2010PET\/CT): A Case Report","volume":"9","author":"Honnorat E.","year":"2016","journal-title":"BMC Research Notes"},{"issue":"4","key":"e_1_2_12_20_1","first-page":"201","article-title":"Brain Abscess in a Third\u2010Level Hospital: Epidemiology and Prognostic Factors Related to Mortality","volume":"22","author":"Gutierrez\u2010Cuadra M.","year":"2009","journal-title":"Revista Espa\u00f1ola de Quimioterapia"},{"issue":"1","key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cmi.2023.08.016","article-title":"European Society of Clinical Microbiology and Infectious Diseases Guidelines on Diagnosis and Treatment of Brain Abscess in Children and Adults","volume":"30","author":"Bodilsen J.","year":"2024","journal-title":"Clinical Microbiology and Infection"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72056","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T04:25:09Z","timestamp":1777004709000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,23]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/ccr3.72056"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72056","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,23]]},"assertion":[{"value":"2025-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72056"}}