{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:34:16Z","timestamp":1773005656757,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Rhabdomyolysis is conventionally treated with aggressive fluid resuscitation and elimination of the inciting factor, whereas corticosteroids are typically limited to cases of immune\u2010mediated myopathy. We describe an 18\u2010year\u2010old female who developed profound bilateral lower\u2010limb swelling, bullae formation, and motor weakness following a viral prodrome. Laboratory evaluation revealed creatine phosphokinase exceeding 2000\u2009IU\/L (estimated by the laboratory staff to be \u2248\u200912,000\u2009IU\/L) and marked transaminitis with preserved renal function. Despite intensive hydration and low\u2010dose corticosteroids, clinical and biochemical progression persisted, and extensive diagnostic workup remained negative. On hospital Day 9, intravenous methylprednisolone 500\u2009mg daily was administered for three consecutive days. This was followed by rapid resolution of symptoms, normalization of muscle enzymes, and complete functional recovery by 3\u2009months. The case suggests that early pulse corticosteroid therapy may avert irreversible muscle damage in selected patients with refractory rhabdomyolysis exhibiting inflammatory characteristics.<\/jats:p>","DOI":"10.1002\/ccr3.72057","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T03:52:37Z","timestamp":1771386757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulse Steroid Therapy in a Patient With Refractory Rhabdomyolysis of Unknown Etiology: A Case Report"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4928-9426","authenticated-orcid":false,"given":"Mustafa","family":"Majid","sequence":"first","affiliation":[{"name":"Baghdad Medical City  Baghdad Iraq"},{"name":"College of Medicine University of Baghdad  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahraa","family":"Alawsi","sequence":"additional","affiliation":[{"name":"Baghdad Teaching Hospital  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab Saeed","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Baghdad Medical City  Baghdad Iraq"},{"name":"College of Medicine University of Baghdad  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaldoon","family":"Sattar","sequence":"additional","affiliation":[{"name":"Baghdad Teaching Hospital  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9140-5860","authenticated-orcid":false,"given":"Asal","family":"Adnan","sequence":"additional","affiliation":[{"name":"Baghdad Medical City  Baghdad Iraq"},{"name":"College of Medicine University of Baghdad  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalddun ahmed","family":"Awad","sequence":"additional","affiliation":[{"name":"Baghdad Teaching Hospital  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Nadhim","sequence":"additional","affiliation":[{"name":"Baghdad Teaching Hospital  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Baghdad Medical City  Baghdad Iraq"},{"name":"College of Medicine University of Al\u2010Nahrain  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4298-5456","authenticated-orcid":false,"given":"Ali Saad","family":"Al\u2010Shammari","sequence":"additional","affiliation":[{"name":"Baghdad Teaching Hospital  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9699-4665","authenticated-orcid":false,"given":"Mohammed Tareq","family":"Mutar","sequence":"additional","affiliation":[{"name":"Baghdad Medical City  Baghdad Iraq"},{"name":"College of Medicine University of Baghdad  Baghdad Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8995-1058","authenticated-orcid":false,"given":"Ibrahim","family":"Khalil","sequence":"additional","affiliation":[{"name":"Dhaka Medical College and Hospital  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_2_14_2_1","volume-title":"Harrison's Principles of Internal Medicine","author":"Longo D. L.","year":"2026"},{"key":"e_1_2_14_3_1","volume-title":"Davidson's Principles and Practice of Medicine","author":"Ralston S. H.","year":"2022"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24606"},{"key":"e_1_2_14_5_1","volume-title":"StatPearls","author":"Rout P.","year":"2025"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc2978"},{"issue":"2","key":"e_1_2_14_7_1","first-page":"61","article-title":"Rhabdomyolysis: Revisited","volume":"90","author":"Gupta A.","year":"2021","journal-title":"Ulster Medical Journal"},{"key":"e_1_2_14_8_1","unstructured":"Norfolk and Norwich University Hospitals NHS Foundation Trust \u201cJoint Trust Guideline for the Management of Methylprednisolone Sodium Succinate Infusion for Child or Young Person (Version 2.6) \u201d A Clinical Guideline (2022) https:\/\/www.nnuh.nhs.uk\/publication\/download\/methylprednisolone\u2010sodium\u2010succinate\u2010infusion\u2010jcg0049\u2010v2\u20106\/."},{"key":"e_1_2_14_9_1","volume-title":"UpToDate","author":"Zager R. A.","year":"2024"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.12552"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.905196"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:11:28Z","timestamp":1772997088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.72057"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72057","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72057"}}