{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:57:07Z","timestamp":1772999827236,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Antisynthetase syndrome is a rare autoimmune disorder characterized by a range of clinical features, most commonly associated with autoantibodies targeting aminoacyl\u2010tRNA synthetases. The condition typically presents with a combination of symptoms, including myositis, arthritis, Raynaud's phenomenon, \u201cmechanic's hands,\u201d fever, and interstitial lung involvement. Pulmonary manifestations, particularly interstitial lung disease (ILD), are significant prognostic determinants. Management often involves a combination of immunosuppressive agents to address both muscular and respiratory complications. We report the case of a 38\u2010year\u2010old man who developed progressive proximal muscle weakness, arthralgia, Raynaud's phenomenon, and ILD. Laboratory tests indicated elevated muscle enzymes, and anti\u2010Jo\u20101 antibodies were detected on repeat testings. Electromyography supported a diagnosis of myopathy, while high\u2010resolution computed tomography confirmed ILD. He was treated with corticosteroids, additional immunosuppressants, and plasmapheresis, which resulted in partial symptomatic improvement. Rituximab was considered a potential future treatment option. This case emphasizes the importance of early recognition and prompt, intensive immunosuppressive therapy, along with careful clinical monitoring, to improve outcomes for patients with severe antisynthetase syndrome.<\/jats:p>","DOI":"10.1002\/ccr3.72059","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T05:37:35Z","timestamp":1771393055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case Report of Antisynthetase Syndrome With Progressive Myopathy and Interstitial Lung Disease in a 38\u2010Year\u2010Old Male"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8599-6861","authenticated-orcid":false,"given":"Masab","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Punjab Medical College  Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Umair","family":"Tariq","sequence":"additional","affiliation":[{"name":"Department of Neurology Allied Hospital  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6747-7980","authenticated-orcid":false,"given":"Muhammad","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Punjab Medical College  Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5248-0749","authenticated-orcid":false,"given":"Muhammad Husnain","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine S Tentishev Asian Medical Institute  Kant Kyrgyzstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"Jamil","sequence":"additional","affiliation":[{"name":"Aziz Fatimah Medical &amp; Dental College  Faisalabad Punjab Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084453"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/2397198320902667"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.09.020"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000663"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2020.101503"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.11477\/mf.1416202432"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867322666150514094935"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.959653"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2024.152479"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.8753"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/CPM.0000000000000171"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72059","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72059","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:23:32Z","timestamp":1772990612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.72059"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72059","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72059"}}