{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:37:01Z","timestamp":1773005821931,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hyperemesis gravidarum\u2010induced Wernickes\u2013Korsakoff syndrome (WKS) is an uncommon but potentially devastating disorder in pregnancy characterized by oculomotor abnormalities, cerebellar dysfunction, and either an altered mental state or mild memory impairment. However, most cases may not display the full spectrum of clinical abnormalities, we report a 34\u2010year\u2010old woman at 15\u2009weeks of gestation who presented with all typical features of WKS, which includes worsening confusion, an unsteady gait, visual symptoms, and episodes of disorientation after two months of relentless vomiting. Clinical evaluation revealed dehydration, horizontal nystagmus, early papilledema, and biochemical evidence of malnutrition. MRI confirmed the diagnosis of WE. She responded to high\u2010dose intravenous thiamine, electrolyte replacement, nutritional support, and ICU\u2010level care. Neuropsychiatric symptoms, including impaired concentration, recent memory loss, and hallucinations, gradually resolved. She was discharged in stable condition after 26\u2009days and demonstrated significant recovery with a normal fetal scan at follow\u2010up. This case highlights the timely need for multidisciplinary treatment modalities and high\u2010dose thiamine supplementation in pregnant women with severe hyperemesis to prevent irreversible neurological injury.<\/jats:p>","DOI":"10.1002\/ccr3.72065","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:54:01Z","timestamp":1771473241000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wernicke\u2013Korsakoff Syndrome a Rare Complication of Hyperemesis Gravidarum: Case Report"],"prefix":"10.1002","volume":"14","author":[{"given":"Ayush","family":"Neupane","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Chitwan Medical College  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7901-8216","authenticated-orcid":false,"given":"Anil","family":"Shahi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chitwan Medical College  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bishaka","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Chitwan Medical College  Bharatpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010025\u201007830\u20107"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2025.154605"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44093"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1941874420953027"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.42766"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_1466_20"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/FM9.0000000000000198"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1080611"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47270"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.5811\/cpcem.20522"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.10012"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/crcc\/7607058"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972\u20105229.128706"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:17:40Z","timestamp":1772997460000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.72065"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72065","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72065"}}