{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:14:55Z","timestamp":1773011695610,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Case Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Crigler\u2013Najjar syndrome type II (CNS\u2010II) is an uncommon cause of persistent unconjugated hyperbilirubinemia resulting from partial deficiency of hepatic UDP\u2010glucuronosyltransferase activity. We report the case of a 19\u2010year\u2010old male who presented with intermittent jaundice since childhood and recent worsening of scleral icterus. Laboratory evaluation revealed isolated unconjugated hyperbilirubinemia with normal liver enzymes. Genetic testing was unavailable; however, serum bilirubin levels declined significantly following phenobarbital therapy, confirming the diagnosis of CNS\u2010II. Abdominal ultrasonography demonstrated gallstones, indicating chronic bilirubin supersaturation secondary to longstanding hyperbilirubinemia. The patient was managed conservatively with phenobarbital and counseling on avoiding precipitating factors such as fasting and hepatotoxic drugs. This case underscores the importance of recognizing CNS\u2010II as a differential diagnosis in young adults with isolated unconjugated hyperbilirubinemia and cholelithiasis. It also highlights phenobarbital responsiveness as a valuable diagnostic tool in settings lacking molecular testing.<\/jats:p>","DOI":"10.1002\/ccr3.72080","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T04:03:00Z","timestamp":1771473780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Childhood Icterus to Adolescent Gallstones: Clinically Diagnosed Crigler\u2010Najjar Syndrome Type\n                    <scp>II<\/scp>"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6209-4048","authenticated-orcid":false,"given":"Danish Kumar","family":"Goswami","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Liaquat University of Medical and Health Sciences  Jamshoro Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3435-6237","authenticated-orcid":false,"given":"Barkha","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liaquat University of Medical and Health Sciences  Jamshoro Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8237-9080","authenticated-orcid":false,"given":"Samiullah","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liaquat University of Medical and Health Sciences  Jamshoro Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5256-393X","authenticated-orcid":false,"given":"Abdul Ghani","family":"Rahimoon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liaquat University of Medical and Health Sciences  Jamshoro Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0253-1137","authenticated-orcid":false,"given":"Rakesh","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Liaquat University of Medical and Health Sciences  Jamshoro Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8208-0689","authenticated-orcid":false,"given":"Kamil Ahmad","family":"Kamil","sequence":"additional","affiliation":[{"name":"Mirwais Regional Hospital  Kandahar Afghanistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,18]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Crigler\u2010Najjar Syndrome. StatPearls [Internet]","author":"Bhandari J.","year":"2025"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/pl00014330"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876\u2010016\u20100449\u20109"},{"key":"e_1_2_12_5_1","first-page":"806","article-title":"Crigler\u2010Najjar Syndrome Type II Diagnosed in a Patient With Jaundice Since Birth","volume":"28","author":"Liaqat A.","year":"2018","journal-title":"Journal of the College of Physicians and Surgeons\u2010Pakistan JCPSP"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176\u2010199902000\u201000024"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3329\/fmcj.v15i1.49011"},{"key":"e_1_2_12_8_1","unstructured":"CARE Case Report Guidelines [Internet] \u201cCARE Case Rep. Guidel \u201dhttps:\/\/www.care\u2010statement.org."},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2018.1428526"},{"key":"e_1_2_12_10_1","volume-title":"Gilbert Syndrome. StatPearls [Internet]","author":"Grant L. M.","year":"2025"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/28195.10221"},{"key":"e_1_2_12_12_1","unstructured":"\u201cDiagnosis and management of Crigler\u2010Najjar syndrome \u2010 PubMed [Internet] \u201dhttps:\/\/pubmed.ncbi.nlm.nih.gov\/10603107\/."},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1354514"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098\u20101004(200010)16:4%3C297::AID\u2010HUMU2%3E3.0.CO;2\u2010Z"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3126\/jnps.v35i1.10620"},{"issue":"3","key":"e_1_2_12_16_1","first-page":"114","article-title":"Delayed Diagnosis of Crigler\u2010Najjar Disease: A Case Report of a 17\u2010Year\u2010Old Man with Progressive Jaundice","volume":"9","author":"Beigvand P.","year":"2024","journal-title":"Case Reports in Clinical Practice [Internet]"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.08.010"}],"container-title":["Clinical Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccr3.72080","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccr3.72080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:43:27Z","timestamp":1773006207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccr3.72080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/ccr3.72080"],"URL":"https:\/\/doi.org\/10.1002\/ccr3.72080","archive":["Portico"],"relation":{},"ISSN":["2050-0904","2050-0904"],"issn-type":[{"value":"2050-0904","type":"print"},{"value":"2050-0904","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72080"}}